Zhang Min, Shu Hongyang, Chen Chen, He Zuowen, Zhou Zhou, Wang Dao Wen
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan 430030, China.
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan 430030, China.
Biomed Pharmacother. 2022 Sep;153:113326. doi: 10.1016/j.biopha.2022.113326. Epub 2022 Jun 24.
Heart failure with preserved ejection fraction (HFpEF) reduces the quality of life, costs substantial medical resources, and has a high mortality. However, we lack an effective therapy for HFpEF due to our limited knowledge of its mechanism. Therefore, it is crucial to explore novel therapeutics, such as those with endogenous protective roles, and seek new targeted therapies. Epoxyeicosatrienoic acids (EETs) are endogenous bioactive metabolites of arachidonic acids produced by cytochrome P450 (CYP) epoxygenases. EETs can function as endogenous cardioprotective factors with potent inhibitory roles in inflammation, endothelial dysfunction, cardiac remodeling, and fibrosis, which are the fundamental mechanisms of HFpEF. This suggests that EETs have the potential function to protect against HFpEF. Therefore, we present an overview of the ever-expanding world of EETs and how they might help alleviate the pathophysiology underlying HFpEF to provide new insights for research in this field.
射血分数保留的心力衰竭（HFpEF）会降低生活质量，耗费大量医疗资源，且死亡率很高。然而，由于我们对其机制的了解有限，目前缺乏针对HFpEF的有效治疗方法。因此，探索新型治疗方法，如具有内源性保护作用的治疗方法，并寻找新的靶向治疗方法至关重要。环氧二十碳三烯酸（EETs）是细胞色素P450（CYP）环氧合酶产生的花生四烯酸的内源性生物活性代谢产物。EETs可作为内源性心脏保护因子，对炎症、内皮功能障碍、心脏重塑和纤维化具有强大的抑制作用，而这些正是HFpEF的基本机制。这表明EETs具有预防HFpEF的潜在功能。因此，我们概述了不断扩展的EETs领域，以及它们如何有助于缓解HFpEF的病理生理学，为该领域的研究提供新的见解。
