Department of Cardiology, Hospital de Alta Complejidad El Cruce, Florencio Varela, Buenos Aires. Argentina; GEDIC, Grupo de Estudio, Docencia e Investigación Clínica, Buenos Aires, Argentina.
Department of Cardiology, Hospital General de Agudos Dr. Cosme Argerich, Buenos Aires, Argentina; Department of Internal Medicine, Instituto Alexander Fleming, Buenos Aires, Argentina.
Curr Probl Cardiol. 2022 Oct;47(10):101300. doi: 10.1016/j.cpcardiol.2022.101300. Epub 2022 Jun 24.
The clinical presentation of acute coronary syndromes (ACS) as ST-elevation ACS (STEACS) or non-ST-elevation ACS (NSTEACS) differs between women and men. The aim of this study was to describe the difference in the clinical presentation of ACS between sexes. A total of 10,019 patients included in the Epi-Cardio Registry were analyzed. A higher proportion of women than men presented with NSTEACS (60.3% vs 46.7%; P <0.001). The difference between sexes was driven by a higher prevalence of ACS with non-obstructive coronary arteries (20.9% vs 6.6%) mainly in young women, since ACS without coronary lesions were mostly NSTEACS (77.7% vs 22.3%). In patients with obstructive coronary heart disease, there were no differences in the clinical presentation between sexes. In conclusion, younger women are more likely than men to present ACS with non-obstructive coronary arteries, whereas no significant difference exists between sexes regarding the prevalence of ACS with obstructive coronary artery disease.
急性冠状动脉综合征（ACS）的临床表现分为 ST 段抬高型 ACS（STEACS）和非 ST 段抬高型 ACS（NSTEACS），女性和男性之间存在差异。本研究旨在描述 ACS 临床表现的性别差异。共分析了 Epi-Cardio 注册中心纳入的 10019 例患者。与男性相比，女性中 NSTEACS 的比例更高（60.3%比 46.7%；P<0.001）。这种性别差异是由于非阻塞性冠状动脉疾病所致 ACS 的发生率更高（20.9%比 6.6%），主要是在年轻女性中，因为无冠状动脉病变的 ACS 大多为 NSTEACS（77.7%比 22.3%）。在阻塞性冠心病患者中，男女之间的临床表现无差异。总之，年轻女性比男性更有可能出现非阻塞性冠状动脉所致 ACS，而在阻塞性冠状动脉疾病所致 ACS 的患病率方面，男女之间没有显著差异。
