Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan 430074, China.
Research Unit of Multimodal Cross Scale Neural Signal Detection and Imaging, HUST-Suzhou Institute for Brainsmatics, JITRI, Chinese Academy of Medical Sciences, Suzhou 215004, China.
Int J Mol Sci. 2023 Aug 14;24(16):12790. doi: 10.3390/ijms241612790.
Compared to young people and adults, there are differences in the ability of elderly people to resist diseases or injuries, with some noticeable features being gender-dependent. However, gender differences in age-related viscera alterations are not clear. To evaluate a potential possibility of gender differences during the natural aging process, we used three age groups to investigate the impact on spleens, kidneys, and adrenal glands. The immunofluorescence results showed that male-specific p21 proteins were concentrated in the renal tubule epithelial cells of the kidney. Histological staining revealed an increase in the frequencies of fat vacuoles located in the renal tubule epithelial cells of the cortex, under the renal capsule in the kidneys of male mice with age. In female mice, we found that the width of the globular zone in the adrenal gland cortex was unchanged with age. On the contrary, the male displayed a reduction in width. Compared to females, the content of epinephrine in adrenal gland tissue according to ELISA analysis was higher in adults, and a greater decline was observed in aged males particularly. These data confirmed the age-dependent differences between female and male mice; therefore, gender should be considered one of the major factors for personalized treatment in clinical diagnosis and treatment.
与年轻人和成年人相比，老年人抵抗疾病或伤害的能力存在差异，一些明显的特征是性别依赖性的。然而，与年龄相关的内脏变化在性别上的差异尚不清楚。为了评估在自然衰老过程中潜在的性别差异的可能性，我们使用了三个年龄组来研究对脾脏、肾脏和肾上腺的影响。免疫荧光结果表明，男性特异性的 p21 蛋白集中在肾脏的肾小管上皮细胞中。组织学染色显示，随着年龄的增长，雄性小鼠肾脏的肾包膜下肾皮质的肾小管上皮细胞中的脂肪空泡频率增加。在雌性小鼠中，我们发现随着年龄的增长，肾上腺皮质的球状带宽度不变。相反，雄性的宽度减小。与女性相比，根据 ELISA 分析，肾上腺组织中的肾上腺素含量在成年期较高，而老年雄性的下降更为明显。这些数据证实了雌性和雄性小鼠之间存在年龄依赖性差异；因此，性别应被视为临床诊断和治疗中个性化治疗的主要因素之一。
