Dumitriu L, Mogoş I, Taşcă C
Endocrinologie. 1987 Jan-Mar;25(1):25-39.
Given the endemic goiter in Romania, the authors sought to evaluate the morphologic prognostic factors with histogenetic implications in the development of thyroid cancer. On this purpose, the morphologic factors that correlate the type of thyroid cancer to the host stromal alterations were studied on 3 groups of 20 patients each and 2 control lots for multinodular goiter and nodular goiter. One group consisted of cases of thyroid carcinoma associated with endemic goiter, the second group included cases of thyroid carcinoma with thyroiditis and nodular goiter and the third group, the cases of thyroid sclerosing occult carcinoma. The study showed in all the cases, that thyroid cancer evoluates as an autonomic lesion, independent of the endemic goiter which is not a risk factor.
鉴于罗马尼亚存在地方性甲状腺肿，作者试图评估在甲状腺癌发生过程中具有组织发生学意义的形态学预后因素。为此，对3组各20例患者以及2组多结节性甲状腺肿和结节性甲状腺肿对照样本进行了研究，分析了将甲状腺癌类型与宿主基质改变相关联的形态学因素。第一组由与地方性甲状腺肿相关的甲状腺癌病例组成，第二组包括伴有甲状腺炎和结节性甲状腺肿的甲状腺癌病例，第三组为甲状腺隐匿性硬化癌病例。研究表明，在所有病例中，甲状腺癌作为一种自主性病变发展，与地方性甲状腺肿无关，地方性甲状腺肿并非危险因素。
