Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Centre for Neuroscience of Speech, University of Melbourne, Melbourne, VIC, Australia.
Cerebellum. 2023 Aug;22(4):761-775. doi: 10.1007/s12311-022-01435-y. Epub 2022 Jun 27.
Multiple sclerosis (MS) is a progressive disease that often affects the cerebellum. It is characterised by demyelination, inflammation, and neurodegeneration within the central nervous system. Damage to the cerebellum in MS is associated with increased disability and decreased quality of life. Symptoms include gait and balance problems, motor speech disorder, upper limb dysfunction, and oculomotor difficulties. Monitoring symptoms is crucial for effective management of MS. A combination of clinical, neuroimaging, and task-based measures is generally used to diagnose and monitor MS. This paper reviews the present and new tools used by clinicians and researchers to assess cerebellar impairment in people with MS (pwMS). It also describes recent advances in digital and home-based monitoring for people with MS.
多发性硬化症（MS）是一种进展性疾病，常影响小脑。其特征是中枢神经系统内脱髓鞘、炎症和神经退行性变。MS 小脑损伤与残疾增加和生活质量下降有关。症状包括步态和平衡问题、运动性言语障碍、上肢功能障碍和眼球运动困难。监测症状对 MS 的有效管理至关重要。通常使用临床、神经影像学和基于任务的措施相结合来诊断和监测 MS。本文综述了临床医生和研究人员用于评估 MS 患者（pwMS）小脑损伤的现有和新工具。它还描述了 MS 患者数字和家庭监测的最新进展。
