Department of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
School of Health Sciences, Prefectural University of Hiroshima, Hiroshima, Japan.
J Physiol Anthropol. 2022 Jun 27;41(1):25. doi: 10.1186/s40101-022-00299-9.
This study aims to compare the effects of soy protein isolate (SPI) and soy peptide (PEP) preload 30 min before a 75-g oral glucose tolerance test (OGTT) on the gastric emptying rate, plasma insulin, and blood glucose responses.
Nine healthy young subjects were evaluated on four occasions. The participants consumed a 200-ml solution containing either 20 g of SPI or PEP in experiment 1. In experiment 2, 30 min after consuming either 20 g of SPI or PEP solutions, an OGTT was performed to evaluate the individual glycemic response. The gastric emptying rate was measured by the C-sodium acetate breath test. Blood glucose and plasma insulin were measured before and after consuming either the SPI or PEP solutions and during the OGTT.
In experiment 1, plasma insulin levels were higher 30 min after consuming the PEP solution than after the SPI solution. PEP resulted in a faster gastric emptying rate than SPI. In experiment 2, just before performing the OGTT, the plasma insulin response was higher for PEP than for SPI. Fifteen minutes after starting the OGTT, the blood glucose response was lower after consuming PEP than after SPI. The gastric emptying rate tended to be faster after consuming PEP than after SPI (p = 0.08).
A PEP preload might be slightly more effective for the suppression of postprandial blood glucose excursion compared with SPI; thus, a PEP preload potentially induces an enhanced insulin response just before the OGTT.
本研究旨在比较口服葡萄糖耐量试验（OGTT）前 30 分钟摄入大豆分离蛋白（SPI）和大豆肽（PEP）对胃排空率、血浆胰岛素和血糖反应的影响。
9 名健康年轻受试者在 4 次试验中进行了评估。参与者在实验 1 中分别摄入 200ml 含 20g SPI 或 PEP 的溶液。在实验 2 中，摄入 20g SPI 或 PEP 溶液 30 分钟后，进行 OGTT 以评估个体血糖反应。胃排空率通过 C-醋酸钠呼气试验测量。在摄入 SPI 或 PEP 溶液前后以及 OGTT 期间测量血糖和血浆胰岛素。
在实验 1 中，摄入 PEP 溶液 30 分钟后血浆胰岛素水平高于 SPI 溶液。PEP 导致胃排空率快于 SPI。在实验 2 中，在进行 OGTT 之前，PEP 的血浆胰岛素反应高于 SPI。OGTT 开始后 15 分钟，摄入 PEP 后血糖反应低于 SPI。与 SPI 相比，摄入 PEP 后胃排空率趋于更快（p=0.08）。
与 SPI 相比，PEP 负荷可能对抑制餐后血糖波动更有效；因此，PEP 负荷可能会在 OGTT 前引起增强的胰岛素反应。
