Koskela R S, Klockars M, Järvinen E, Kolari P J, Rossi A
Scand J Work Environ Health. 1987 Feb;13(1):18-25. doi: 10.5271/sjweh.2085.
The objective of the present study was to investigate the mortality, disability, and long-term morbidity of granite workers. The study included 1,026 workers hired between 1940 and 1971 and followed until the end of 1981. The total number of deaths was 235, and the expected number was 229.7. Excess mortality rates were observed for respiratory diseases (observed/expected = 28/13.9). The number of tumor deaths was 46 (expected 44.9). Excess lung cancer mortality was evident at 15 to 35 years of latency; the observed number of lung cancer deaths for the follow-up period of 25 to 29 years was 8, while 2.1 were expected. Mortality from cardiovascular diseases and violent deaths was slightly less than expected. The results for disability and long-term morbidity showed elevated incidence and prevalence rates for respiratory diseases and rheumatoid arthritis. The observed number of disability pensions due to rheumatoid arthritis in 1981 was 10 observed versus 1.8 expected, and the observed number of patients granted free medication was 19 versus 8.1 expected. The results indicate that granite dust exposure per se may be an etiologic and pathogenetic factor for lung cancer, cancer of the gastrointestinal tract, and some extrapulmonary nonmalignant chronic diseases.
本研究的目的是调查花岗岩工人的死亡率、残疾率和长期发病率。该研究纳入了1940年至1971年间雇佣的1026名工人,并随访至1981年底。死亡总数为235人,预期死亡数为229.7人。观察到呼吸系统疾病的超额死亡率(观察值/预期值=28/13.9)。肿瘤死亡人数为46人(预期为44.9人)。在潜伏15至35年时,肺癌超额死亡率明显;在25至29年的随访期内,观察到的肺癌死亡人数为8人,而预期为2.1人。心血管疾病和暴力死亡的死亡率略低于预期。残疾和长期发病情况的结果显示,呼吸系统疾病和类风湿性关节炎的发病率和患病率有所升高。1981年因类风湿性关节炎领取残疾抚恤金的观察人数为10人,预期为1.8人,获得免费药物治疗的患者观察人数为19人,预期为8.1人。结果表明,接触花岗岩粉尘本身可能是肺癌、胃肠道癌和一些肺外非恶性慢性病的病因和发病因素。