Mastrangelo G, Zambon P, Simonato L, Rizzi P
Center of Environmental Carcinogenesis, University of Padova, Italy.
Int Arch Occup Environ Health. 1988;60(4):299-302. doi: 10.1007/BF00378477.
A case-referent study was carried out to investigate the relationship between lung cancer and exposure to silica dust in an area where a relatively high proportion of the workforce was exposed to silica dust in the past. The cases were 309 lung cancer patients admitted at the Chest Department of the Central Belluno Hospital during the period 1973-1980, while the 309 controls were patients admitted at the same department for diseases other than lung cancer and bronchitis during the same period. Information on exposure to silica and smoking habits were collected from hospital records. The results show an elevated risk, supported by a clear dose-response, due to smoking. Exposure to silica also appears to increase the risk of lung cancer, but only in presence of silicosis. The risk estimates tend to increase both with amount of smoking and duration of exposure to silica, with the magnitude of the risk being, however, much smaller for the latter effect. No clear interaction appears to exist between the two factors. The limitations of the study and the problems in interpreting the results are discussed.
在一个过去有相对较高比例劳动力接触二氧化硅粉尘的地区，开展了一项病例对照研究，以调查肺癌与接触二氧化硅粉尘之间的关系。病例为1973年至1980年期间在贝卢诺中心医院胸科住院的309例肺癌患者，而309名对照是同期在同一科室因肺癌和支气管炎以外的疾病住院的患者。从医院记录中收集了接触二氧化硅和吸烟习惯的信息。结果显示，由于吸烟，风险升高，且有明确的剂量反应。接触二氧化硅似乎也会增加患肺癌的风险，但仅在患有矽肺病的情况下。风险估计值往往随着吸烟量和接触二氧化硅的持续时间而增加，然而，后一种影响的风险程度要小得多。这两个因素之间似乎没有明显的相互作用。讨论了该研究的局限性以及解释结果时存在的问题。
