Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
Geriatr Gerontol Int. 2011 Jan;11(1):77-82. doi: 10.1111/j.1447-0594.2010.00645.x. Epub 2010 Aug 30.
Some patients with mild cognitive impairment (MCI) may have impaired frontal lobe function. To assess the frontal lobe functions of subjects with MCI using the Frontal Assessment Battery (FAB) and to identify the brain regions responsible for FAB performance.
Based on the FAB score cut-off of 12/13, 38 MCI subjects were divided into a high FAB group (n=20) and a low FAB group (n=18). They underwent single photon emission computed tomography (SPECT) and we analyzed the data by the 3-D stereotactic surface projection method.
No significant differences in neuropsychological tests including memory, language and praxis, and depression scores were found between high and low FAB groups. Although both groups showed decreases in the regional cerebral blood flow (rCBF) of the parietotemporal and frontal regions, the low FAB group demonstrated significant decreases in the rCBF of the left lateral frontal and right medial frontal regions compared with the high FAB group.
Our results indicate that some patients with amnestic MCI have frontal lobe dysfunction, assessed by the FAB. SPECT study suggests that the FAB mainly reflects the function of some regions of the left lateral frontal and right medial frontal areas.
一些轻度认知障碍（MCI）患者可能存在额叶功能障碍。本研究旨在使用额叶评估量表（FAB）评估 MCI 患者的额叶功能，并确定与 FAB 表现相关的脑区。
根据 FAB 评分 12/13 的截断值，将 38 例 MCI 患者分为高 FAB 组（n=20）和低 FAB 组（n=18）。所有患者均行单光子发射计算机断层扫描（SPECT）检查，采用三维立体定向表面投影法对数据进行分析。
高 FAB 组和低 FAB 组间记忆、语言和操作等神经心理学测试及抑郁评分均无显著差异。两组患者均表现出顶颞叶和额叶区域的局部脑血流（rCBF）减少，但与高 FAB 组相比，低 FAB 组患者左侧额外侧和右侧额内侧区域的 rCBF 减少更为显著。
本研究结果表明，部分遗忘型 MCI 患者存在额叶功能障碍，可通过 FAB 进行评估。SPECT 研究提示 FAB 主要反映了左侧额外侧和右侧额内侧部分区域的功能。
