UMR Transfrontalière BioEcoAgro N° 1158, Univ. Lille, INRAE, Univ. Liège, UPJV, YNCREA, Univ. Artois, Univ. Littoral Côte d'Opale, ICV - Institut Charles Viollette, F-59000 Lille, France.
UMR Transfrontalière BioEcoAgro N° 1158, Univ. Lille, INRAE, Univ. Liège, UPJV, YNCREA, Univ. Artois, Univ. Littoral Côte d'Opale, ICV - Institut Charles Viollette, F-59000 Lille, France.
Food Res Int. 2022 Jul;157:111360. doi: 10.1016/j.foodres.2022.111360. Epub 2022 May 20.
Milk and dairy products are significant sources of proteins and peptides impacting human health. In this way, the interest in CPPs, bioactive phosphorylated peptides resulting from the hydrolysis of caseins, has grown in the past years. CPPs were mainly studied for their capacity to chelate and increase the bioavailability of essential minerals involved in multiple physiological processes. Moreover, CPPs harbour interesting antioxidant and anti-inflammatory properties. Recent in vivo and in vitro studies demonstrated that these different roles are strongly linked to the intrinsic properties of CPPs and CPP concentrate preparations. This review first comments on the different methods of CPP analytical characterization, focusing on recent techniques. Then, the CPP release occurring during the gastrointestinal digestion was reviewed, followed by the different CPP obtention processes and their impact on their physicochemical characteristics. Finally, the different bioactive roles attributed to CPPs, including mineral chelating properties, are discussed. We show that CPPs have a promising role in treating various pathologies, notably to compensate for deficiencies in certain nutrients and an anti-oxidant and anti-inflammatory role. Nevertheless, the mechanisms by which CPPs exert their role remain to be elucidated, and this requires precise characterization of CPPs. This work highlights the key parameters to be considered to study and produce CPPs and the different ways to be investigated in the future to elucidate their roles in vivo and characterize their potential for human health.
奶及奶制品是影响人类健康的蛋白质和肽类的重要来源。因此，近年来人们对酪蛋白水解产生的具有生物活性的磷酸肽（CPPs）越来越感兴趣。CPPs 主要因其螯合和提高参与多种生理过程的必需矿物质生物利用度的能力而被研究。此外，CPPs 还具有有趣的抗氧化和抗炎特性。最近的体内和体外研究表明，这些不同的作用与 CPPs 和 CPP 浓缩物制剂的固有特性密切相关。这篇综述首先评论了 CPP 分析特性的不同方法，重点是最近的技术。然后，综述了 CPP 在胃肠道消化过程中的释放情况，接着讨论了 CPP 的不同获得过程及其对其理化特性的影响。最后，讨论了 CPP 所具有的不同生物活性作用，包括矿物质螯合特性。我们表明 CPP 在治疗各种疾病方面具有广阔的应用前景，特别是在弥补某些营养物质的缺乏以及抗氧化和抗炎方面。然而，CPP 发挥作用的机制仍有待阐明，这需要对 CPP 进行精确的表征。这项工作强调了研究和生产 CPPs 时需要考虑的关键参数，以及未来需要研究的不同方法，以阐明 CPP 在体内的作用并确定其对人类健康的潜力。
