Carvalho Bruno R de, Rodrigues Jhenifer K, Campos Jacira R, Silva Adelino A, Marinho Ricardo M, Silva Ana Carolina J S Rosa E
GENESIS, Center for Assistance in Human Reproduction, Brasília, DF, Brazil.
Brazilian Oncofertility Consortium.
JBRA Assist Reprod. 2014 Mar 27;18(1):16-23. doi: 10.5935/1518-0557.20140087.
Malignant and cardiovascular diseases are the main causes of death in Brazil. Estimates for 2013 predict the occurrence of 189,150 new cases of cancer in Brazilian women. With advanced detection tools, patients are diagnosed and treated for cancer at a younger age and are more likely to survive. The cytotoxic action of chemotherapeutic agents and radiotherapy very frequently implies serious damage to the gonads, and consequences due to the hypoestrogenism, such as osteoporosis, infertility and premature ovarian failure, are expected. Oncofertility, then, appears as a new area of reproductive medicine, which is dedicated to the development of strategies for the reduction of therapeutic sequels in cancer survivals, ultimately aiming the maintenance of their quality of life and the possibility of biological maternity. This article aims to present an overview of possible options for female fertility preservation after cancer and future perspectives in oncofertility.
恶性疾病和心血管疾病是巴西的主要死因。2013年的估计数据显示，巴西女性预计会出现189,150例新发癌症病例。借助先进的检测工具，患者能够在更年轻的时候被诊断出癌症并接受治疗，存活几率也更高。化疗药物和放疗的细胞毒性作用常常会对性腺造成严重损害，预计会出现因雌激素缺乏而导致的后果，如骨质疏松、不孕和卵巢早衰。于是，肿瘤生育学作为生殖医学的一个新领域应运而生，致力于制定策略以减少癌症幸存者的治疗后遗症，最终目标是维持他们的生活质量以及实现生育的可能性。本文旨在概述癌症后女性生育力保存的可能选择以及肿瘤生育学的未来前景。
