Naoum G, Markantonis S L, Fanerou E, Siagkas G, Petropoulos F, Zafiris E, Kousovista R, Karalis V
Internal Medicine Clinic, Athens Medical Center, Distomou Street, Maroussi 15125, Greece.
Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens 15784, Greece.
Gastroenterol Res Pract. 2022 Jun 18;2022:8379579. doi: 10.1155/2022/8379579. eCollection 2022.
The aim of this study was to investigate the relationship between gastrointestinal (GI) symptoms and extragastric manifestations such as headache, fatigue, and dizziness. A prospective cohort study was conducted in a tertiary hospital in Athens, where patients with GI problems and extragastric symptoms were treated only for their GI problems, and improvement in extragastric manifestations was recorded. Inclusion criteria were an age older than 18 years, the presence of at least one of the three extragastric symptoms investigated in this study (headache, dizziness, and fatigue), and the concomitant presence of at least one gastrointestinal symptom (e.g., nausea, belching, abdominal tenderness, epigastric pain, halitosis, flatulence, diarrhea, bad odor of flatulence, flatulence, and constipation). A standardized questionnaire was used to collect demographic data (such as age, weight, and height), patients' symptoms, laboratory findings (gastric biopsy, gastroscopy, and colonoscopy), and intensity/frequency of GI and extragastric symptoms. Statistically significant associations were found between GI symptoms (nausea, constipation, halitosis, and belching) and dizziness, fatigue, and headache (frequency, intensity, and duration). Treatment of GI problems resulted in a significant improvement in extragastric symptoms within one month of treatment initiation. It should be emphasized that the actual reason for the improvement in extragastric symptoms was solely the resolution of the GI problems, as patients did not receive specific treatments for headache, dizziness or fatigue, or other changes in daily life. This study demonstrates the association between extragastric manifestations and GI disorders.
本研究的目的是调查胃肠道（GI）症状与诸如头痛、疲劳和头晕等胃外表现之间的关系。在雅典的一家三级医院进行了一项前瞻性队列研究，在该研究中，患有胃肠道问题和胃外症状的患者仅接受针对其胃肠道问题的治疗，并记录胃外表现的改善情况。纳入标准为年龄大于18岁、存在本研究中调查的三种胃外症状（头痛、头晕和疲劳）中的至少一种，以及同时存在至少一种胃肠道症状（例如恶心、嗳气、腹部压痛、上腹部疼痛、口臭、肠胃胀气、腹泻、肠胃胀气异味、肠胃胀气和便秘）。使用标准化问卷收集人口统计学数据（如年龄、体重和身高）、患者症状、实验室检查结果（胃活检、胃镜检查和结肠镜检查）以及胃肠道和胃外症状的强度/频率。发现胃肠道症状（恶心、便秘、口臭和嗳气）与头晕、疲劳和头痛（频率、强度和持续时间）之间存在统计学上的显著关联。治疗胃肠道问题在开始治疗后的一个月内使胃外症状有显著改善。应该强调的是，胃外症状改善的实际原因仅仅是胃肠道问题的解决，因为患者没有接受针对头痛、头晕或疲劳的特定治疗，也没有日常生活中的其他变化。本研究证明了胃外表现与胃肠道疾病之间的关联。
