da Silva Costa Nathalia, Almeida Patricia Pereira, Da Cruz Beatriz Oliveira, Brito Michele Lima, Maldonado-Campos Johnatas, Menezes Agatha Cristie, Figueiredo Mariana Sarto, Magliano D' Angelo Carlo, Pereira Aline D'Avila, Stockler-Pinto Milena Barcza
Cardiovascular Sciences Graduation Program, Fluminense Federal University (UFF), Niterói, Brazil.
Nutrition Graduation, Fluminense Federal University (UFF), Niterói, Brazil.
J Food Biochem. 2022 Oct;46(10):e14294. doi: 10.1111/jfbc.14294. Epub 2022 Jun 28.
Oxidative stress, adipose tissue, and bone compartments can be disturbed in chronic diseases. Non-pharmacological strategies, such as Brazil nuts (BNs), can improve these parameters. This study evaluated the effects of BN supplementation at different concentrations on body composition, lipid profile, and peroxidation in healthy rats. Male Wistar rats were divided into three groups: control (CT), Brazil nut 5% (BN5), and Brazil nut 10% (BN10) groups. Body composition, brown adipose tissue (BAT), plasma lipid peroxidation, and lipid profile were evaluated in the three groups. The BN5 group showed an improvement in all bone parameters compared with that of the CT group (p < .0001). The BN5 and BN10 groups showed reduced plasma lipid peroxidation compared with that of the CT group (p = .0009), whereas the BN10 group presented lower BAT lipid peroxidation than that of the other groups (p = .01). High-density lipoprotein-cholesterol (HDL-c) levels were higher in the BN5 group than in the CT group (p = .01). Conclusively, the use of BNs in a controlled manner promoted improvement in bone parameters, HDL-c levels, and lipid peroxidation in healthy rats. PRACTICAL APPLICATIONS: Nuts has been included in the diet because of their versatility, acceptance, and easy access. Among them, Brazil nut (BN) is considered one of the major known food sources of selenium as well as a source of fibers, unsaturated fatty acids, and phenolic compounds. Studies have shown that BN supplementation is effective in reducing oxidative stress, inflammation, lipid peroxidation, and selenium deficiency when used as a non-pharmacological strategy in experimental models of chronic diseases and in clinical trials. The present study showed that controlled administration of BN improved bone parameters, high-density lipoprotein-cholesterol levels, and lipid peroxidation in healthy rats. Therefore, BN is a promising non-pharmacological agent for the prevention of the onset of chronic non-communicable diseases.
在慢性疾病中，氧化应激、脂肪组织和骨腔可能会受到干扰。非药物策略，如巴西坚果（BNs），可以改善这些参数。本研究评估了不同浓度的巴西坚果补充剂对健康大鼠身体成分、血脂谱和过氧化作用的影响。雄性Wistar大鼠分为三组：对照组（CT）、5%巴西坚果组（BN5）和10%巴西坚果组（BN10）。对三组大鼠的身体成分、棕色脂肪组织（BAT）、血浆脂质过氧化和血脂谱进行了评估。与CT组相比，BN5组的所有骨参数均有改善（p <.0001）。与CT组相比，BN5组和BN10组的血浆脂质过氧化降低（p =.0009），而BN10组的BAT脂质过氧化低于其他组（p =.01）。BN5组的高密度脂蛋白胆固醇（HDL-c）水平高于CT组（p =.01）。总之，以可控方式使用巴西坚果可促进健康大鼠骨参数、HDL-c水平和脂质过氧化的改善。实际应用：坚果因其多功能性、可接受性和易于获取而被纳入饮食。其中，巴西坚果被认为是主要的已知硒食物来源之一，也是纤维、不饱和脂肪酸和酚类化合物的来源。研究表明，在慢性疾病实验模型和临床试验中，将巴西坚果补充剂用作非药物策略可有效降低氧化应激、炎症、脂质过氧化和硒缺乏。本研究表明，对健康大鼠进行可控剂量的巴西坚果给药可改善骨参数、高密度脂蛋白胆固醇水平和脂质过氧化。因此，巴西坚果是预防慢性非传染性疾病发生的一种有前景的非药物制剂。
