Laboratory of Food & Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, P. O. Box 164, 30100 Campus de Espinardo, Murcia, Spain.
Department of Organic Chemistry, Faculty of Chemistry, University of Murcia, 30100 Murcia, Spain.
Food Funct. 2022 Jul 18;13(14):7487-7493. doi: 10.1039/d2fo01475k.
Resveratrol (RSV) was known to be metabolised by the gut microbiota to dihydroresveratrol, lunularin (LUNU), and (or) 3,4'-dihydroxy--stilbene (DHST). We describe here for the first time that LUNU can be further dehydroxylated, but only at the 3-position, to yield 4-hydroxydibenzyl, a novel metabolite found in human urine after RSV intake in 41 out of 59 healthy participants. In contrast, DHST was not further dehydroxylated, and thus, 4-hydroxy--stilbene was not detected as a gut microbial metabolite of RSV. Faecal incubations confirmed the results.
白藜芦醇（RSV）已知可被肠道微生物群代谢为二氢白藜芦醇、落叶松脂素（LUNU）和（或）3,4'-二羟基-二苯乙烯（DHST）。我们在这里首次描述，LUNU 可进一步去羟基化，但仅在 3 位，生成 4-羟基二苄基，这是在 59 名健康参与者摄入 RSV 后，41 人的尿液中发现的一种新型代谢物。相比之下，DHST 没有进一步去羟基化，因此，4-羟基-二苯乙烯没有被检测为 RSV 的肠道微生物代谢物。粪便孵育实验证实了这一结果。
