Parvin Nargish, Nallapureddy Ramesh Reddy, Mandal Tapas Kumar, Joo Sang W
IEEE Trans Nanobioscience. 2023 Apr;22(2):447-452. doi: 10.1109/TNB.2022.3186941. Epub 2023 Mar 31.
This work has aimed to synthesize less cytotoxic but antibacterial effective materials. Here we synthesized zinc, titanium nanoparticles based multishell hollow spheres (ZnO@TiO2 MSHS) via sequential template approach (STA) and studied their comparative antimicrobial activity with pure zinc and titanium nanoparticles (NPs). Various techniques have been used to explore the physico-chemical properties of the hybrid shells (ZnO@TiO2 MSHS). FTIR, XRD measurements approved the enhanced crystallinity of synthesized hybrid MSHS via STA technique constructed by ZnO, TiO2 NPs. The optical transmittance was enhanced 67.08% for ZnO@TiO2 MSHS where 50.59 %, and 53.32 % of pure ZnO, TiO2 NPs respectively. TEM images showed MSHS made up of zinc and titanium nanoparticles distributed evenly in the structure. The antibacterial activity has been studied and measured via MIZ confirmed that the ZnO@TiO2 multishell hollow spheres exhibit the antibacterial performance. On the other hand the cytotoxicity studies show the cell toxicity was decreased for ZnO@TiO2 MSHS than pure ZnO and TiO2 NPs. So it is recommended that ZnO@TiO2 multishell hollow spheres may be used as a safe and potential antibacterial agent in the field of food packaging, painting, drug delivery and other antibacterial applications.
这项工作旨在合成细胞毒性较小但具有抗菌效果的材料。在此，我们通过顺序模板法（STA）合成了基于锌、钛纳米颗粒的多壳空心球（ZnO@TiO2 MSHS），并研究了它们与纯锌和钛纳米颗粒（NPs）相比的抗菌活性。已使用各种技术来探索混合壳（ZnO@TiO2 MSHS）的物理化学性质。傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）测量证实，通过由ZnO、TiO2 NPs构建的STA技术合成的混合MSHS的结晶度有所提高。ZnO@TiO2 MSHS的光学透过率提高了67.08%，而纯ZnO、TiO2 NPs的光学透过率分别为50.59%和53.32%。透射电子显微镜（TEM）图像显示，MSHS由均匀分布在结构中的锌和钛纳米颗粒组成。通过最小抑菌浓度（MIZ）研究和测量了抗菌活性，证实了ZnO@TiO2多壳空心球具有抗菌性能。另一方面，细胞毒性研究表明，ZnO@TiO2 MSHS的细胞毒性比纯ZnO和TiO2 NPs低。因此，建议ZnO@TiO2多壳空心球可作为食品包装、涂料、药物递送和其他抗菌应用领域中一种安全且有潜力的抗菌剂。
