Knobel J
S Afr Med J. 1987 May 16;71(10):619-20.
Although the results of both radiotherapy and radical surgery for stages IB and IIA carcinoma of the cervix are good, a small percentage of cancers are resistant to radiation therapy. Combined radiation and surgery therefore seems an attractive alternative. A study of 184 patients in whom radium application was followed by radical abdominal hysterectomy and pelvic lymphadenectomy 6 weeks later is reported. The uncorrected 5-year survival rate of 85.7% is not significantly better than results obtained by surgery alone or radiotherapy alone. Some guidelines are suggested to rationalise individual treatment of these patients.
虽然针对IB期和IIA期宫颈癌的放射治疗和根治性手术效果都不错，但仍有一小部分癌症对放射治疗耐药。因此，放疗与手术联合似乎是一个有吸引力的替代方案。本文报告了一项针对184例患者的研究，这些患者先进行镭敷贴治疗，6周后再行根治性腹式子宫切除术和盆腔淋巴结清扫术。未经校正的5年生存率为85.7%，并不显著优于单纯手术或单纯放疗的结果。文中提出了一些指导方针，以便合理地对这些患者进行个体化治疗。
