Department of Epidemiology of Aging, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan; Institute for Health Care Science, Suntory Wellness Ltd., Soraku-gun, Kyoto, Japan.
Department of Epidemiology of Aging, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Neurobiol Aging. 2022 Sep;117:179-188. doi: 10.1016/j.neurobiolaging.2022.05.008. Epub 2022 Jun 3.
The relationship between age-related brain atrophy and long-chain polyunsaturated fatty acid (LCPUFA) intake is not fully understood. This study investigated the association of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (ARA) intake and brain atrophy in non-demented older Japanese people (n = 810, aged 60-89 years) using data sets of a 2-year longitudinal study. Brain volumes were measured using 3D-MRI in the baseline and follow-up periods. The associations of multivariate-adjusted changes in brain volumes with baseline LCPUFA intake were assessed using a general linear model. Higher ARA intake was associated with a smaller decrease in frontal cortex volumes, which was accompanied by a lower risk of cognitive decline among the participants. In the subgroup analysis for low DHA and EPA intake, accounting for one-third of Japanese intake, DHA and EPA intake was positively correlated with preservation of the temporal cortex volume. These findings suggest that appropriate intake of LCPUFA may decelerate age-related brain atrophy and lead to the maintenance of brain health in older people.
年龄相关性脑萎缩与长链多不饱和脂肪酸（LCPUFA）摄入之间的关系尚未完全阐明。本研究使用一项为期 2 年的纵向研究数据集，调查了非痴呆的老年日本人体内二十二碳六烯酸（DHA）、二十碳五烯酸（EPA）和花生四烯酸（ARA）摄入与脑萎缩之间的关系（n=810，年龄 60-89 岁）。在基线和随访期间使用 3D-MRI 测量脑容量。使用一般线性模型评估基线 LCPUFA 摄入与脑容量变化的多变量调整关联。较高的 ARA 摄入与额叶皮质体积减少较小相关，这与参与者认知能力下降的风险降低有关。在低 DHA 和 EPA 摄入的亚组分析中，占日本摄入量的三分之一，DHA 和 EPA 摄入与颞叶皮质体积的保持呈正相关。这些发现表明，适当摄入 LCPUFA 可能会减缓与年龄相关的脑萎缩，并维持老年人的大脑健康。
