Department of Surgical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan; Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Cardiovascular and Thoracic Center, Viet Duc University Hospital, Hanoi Medical University, Hanoi, Viet Nam.
J Formos Med Assoc. 2022 Dec;121(12):2566-2573. doi: 10.1016/j.jfma.2022.06.005. Epub 2022 Jun 25.
Lung transplantation is a therapeutic option for patients with end-stage lung disease. However, the increase in organ demand has surpassed the number of donors, with many patients unable to outlive the long waiting period. This study aimed to assess mortality and its risk factors in patients on the waiting list for lung transplantation in a single medical centre.
All evaluated clinical and laboratory data of the patients with end-stage lung disease assessed for lung transplantation between February 2005 and November 2018 in National Taiwan University Hospital were recorded in the waiting list database. The patients in this study were divided into two groups: survival and death groups.
Between February 2005 and November 2018, 169 patients were enrolled in the waiting list. Thirty-one patients were alive and waiting for the chance of lung transplantation, 56 underwent lung transplantation, and 82 died while waiting. The mean age of all patients was 43.7 years, and 91 were women. The mean body mass index (BMI) was 20.3. The most common blood type was type O. All patients were in New York Heart Association (NYHA) class III or IV. After analysis of the two groups, lower BMI presented as a mortality factor.
This is the first Taiwanese study to describe the mortality factors in patients waiting for lung transplantation. The main factors influencing the survival of these patients were lower BMI, NYHA class IV, and diseases which cause end-stage lung diseases (infection and pulmonary fibrosis).
肺移植是治疗终末期肺病患者的一种治疗选择。然而，器官需求的增加已经超过了供体数量，许多患者无法在漫长的等待期内存活。本研究旨在评估单中心肺移植等待名单上患者的死亡率及其危险因素。
记录了 2005 年 2 月至 2018 年 11 月期间在国立台湾大学医院评估肺移植的终末期肺病患者的所有评估临床和实验室数据，并将其记录在等待名单数据库中。本研究中的患者分为两组：存活组和死亡组。
2005 年 2 月至 2018 年 11 月期间，有 169 名患者入组等待名单。31 名患者存活并等待肺移植机会，56 名患者接受了肺移植，82 名患者在等待过程中死亡。所有患者的平均年龄为 43.7 岁，91 名为女性。平均体重指数（BMI）为 20.3。最常见的血型为 O 型。所有患者均处于纽约心脏协会（NYHA）III 级或 IV 级。对两组进行分析后，较低的 BMI 是死亡的一个危险因素。
这是台湾首例描述肺移植等待患者死亡因素的研究。影响这些患者生存的主要因素是较低的 BMI、NYHA 级 IV 和导致终末期肺病的疾病（感染和肺纤维化）。
