Intensive Care Unit, Hospital of Zhejiang People's Armed Police, Hangzhou, Zhejiang, China.
The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Ann Thorac Cardiovasc Surg. 2024;30(1). doi: 10.5761/atcs.ra.24-00092.
This meta-analysis aimed to compare the prognosis of lung transplantation recipients based on donor age.
A detailed search was performed in PubMed, Embase, Web of Science, and the Cochrane Library for cohort studies on lung transplantation. The prognosis of lung transplant recipients was investigated based on the donor age, with the primary outcomes being 1-year overall survival (OS), 3-year OS, 5-year OS, and 5-year chronic lung allograft dysfunction (CLAD)-free survival.
This meta-analysis included 10 cohort studies. Among the short-term outcomes, the older donor group demonstrated no significant difference from the young donor group in primary graft dysfunction within 72 hours, use of extracorporeal membrane oxygenation, length of ventilator use, and intensive care unit hours. However, a longer hospital stay was associated with the older donor group. In terms of long-term outcomes, no difference was found between the two groups in 1-year OS, 3-year OS, and 5-year OS. Notably, patients with older donors exhibited a superior 5-year CLAD-free survival.
The results of this meta-analysis indicate that older donors are not inferior to younger donors in terms of long-term and short-term recipient outcomes. Lung transplantation using older donors is a potential therapeutic option after rigorous evaluation.
本荟萃分析旨在比较基于供体年龄的肺移植受者预后。
在 PubMed、Embase、Web of Science 和 Cochrane 图书馆中对肺移植的队列研究进行了详细检索。根据供体年龄调查肺移植受者的预后，主要结局为 1 年总生存率（OS）、3 年 OS、5 年 OS 和 5 年无慢性肺移植物功能障碍（CLAD）生存率。
本荟萃分析纳入了 10 项队列研究。在短期结局方面，老年供体组与年轻供体组在 72 小时内原发性移植物功能障碍、体外膜氧合使用、呼吸机使用时间和重症监护病房时间方面无显著差异。然而，老年供体组的住院时间更长。在长期结局方面，两组间 1 年 OS、3 年 OS 和 5 年 OS 无差异。值得注意的是，老年供体组的患者 5 年无 CLAD 生存率更高。
本荟萃分析结果表明，老年供体在长期和短期受者结局方面并不逊于年轻供体。在严格评估后，使用老年供体进行肺移植是一种潜在的治疗选择。
