[瘢痕疙瘩中成纤维细胞特性的研究进展]
[Research advances on the characteristics of fibroblast in keloid].
作者信息
Wang Y Z, Su C, Fu S Q, Liu L Q
机构信息
Department Nine of Plastic Surgery,Plastic Surgery Hospital,Chinese Academy of Medical Sciences, Beijing 100144, China.
Emergency Department, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518033, China.
出版信息
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Jun 20;38(6):590-594. doi: 10.3760/cma.j.cn501120-20210510-00176.
Abstract
In re-cent 20 years, the development of cell biology technology has promoted the research of keloid. Keloid fibroblasts (KFbs) are the main effector cells in keloid, which are closely related to the occurrence and development of keloid. It is significantly different in terms of biological characteristics and gene expression between KFbs and normal fibroblasts. This articles reviews the characteristics of KFbs from multiple perspectives, describing its biological character- istics in details including microstructures, metabolic character- istics, and proliferation properties, and introducing the main characteristics of heterogeneity and genomics of KFbs. The further research on KFbs will help to elucidate the pathogenesis of keloids and provide valuable strategies for the prevention and treatment of keloids.
摘要
在最近20年里，细胞生物学技术的发展推动了瘢痕疙瘩的研究。瘢痕疙瘩成纤维细胞（KFbs）是瘢痕疙瘩中的主要效应细胞，与瘢痕疙瘩的发生和发展密切相关。KFbs与正常成纤维细胞在生物学特性和基因表达方面存在显著差异。本文从多个角度综述了KFbs的特征，详细描述了其生物学特性，包括微观结构、代谢特征和增殖特性，并介绍了KFbs的异质性和基因组学的主要特征。对KFbs的进一步研究将有助于阐明瘢痕疙瘩的发病机制，并为瘢痕疙瘩的预防和治疗提供有价值的策略。
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