Zhu D Z, Yao B, Yan Z Q, Huang S, Fu Xiaobing
Research Center for Wound Repair and Tissue Regeneration, Medical Innovation Research Department, the PLA General Hospital, Beijing 100048, China.
Institute of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Oct 20;38(10):983-988. doi: 10.3760/cma.j.cn501120-20210723-00257.
The scar brings a huge economic burden and creates a serious psychological shadow for patients. Although the current methods for scar treatment tend to be diversified, the treatment method that can truly achieve the goal of "perfect healing" or "scarless healing" after human skin injury is quite scarce. With the wide application of tissue engineering technologies in medicine research, technologies such as three-dimensional bioprinting, organoid culture, and organ chip technologies are constantly emerging. Disease models based on these innovative technologies showed more advantages than traditional animal disease models. The article introduces the current hotspot technologies in skin tissue engineering such as organoid culture, three-dimensional bioprinting, and organ chip technologies, focuses on summarizing the three key elements to be mastered for constructing an ideal scar model , and puts forward the future prospect of constructing an ideal scar model based on our research team's long-term experience in skin tissue repair and regeneration research.
瘢痕给患者带来了巨大的经济负担,并给他们造成了严重的心理阴影。尽管目前瘢痕治疗方法趋于多样化,但人类皮肤损伤后真正能达到“完美愈合”或“无瘢痕愈合”目标的治疗方法却相当稀缺。随着组织工程技术在医学研究中的广泛应用,三维生物打印、类器官培养和器官芯片技术等不断涌现。基于这些创新技术的疾病模型比传统动物疾病模型显示出更多优势。本文介绍了类器官培养、三维生物打印和器官芯片技术等皮肤组织工程领域的当前热点技术,着重总结构建理想瘢痕模型需掌握的三个关键要素,并基于我们研究团队在皮肤组织修复与再生研究方面的长期经验,提出构建理想瘢痕模型的未来展望。