Andriutsa K A, Andriutsa A K
Ter Arkh. 1987;59(2):89-94.
The activity of lactate dehydrogenase (LDH) and its isoenzymes was studied in various biological media in 850 patients with viral hepatitides (VH). The activity of LDH and its isoenzyme LDH5 in the blood serum, formed elements and in the urine of VH patients changed more noticeably in a grave form of disease and in antigen positive VH. A sharp rise of LDH and LDH5 activity in the blood serum of patients with a severe form of VH with its subsequent considerable decrease was indicative of the development of acute liver necrosis. Changes in the activity of LDH and its isoenzymes in the formed blood elements of VH patients pointed out to disturbance in the energetic system influencing their morphological and functional condition. Shifts of LDH and its isoenzymes in the urine of patients indicated renal lesion which could be used for the detection of latent disorders of renal function in VH. A study of the activity of LDH and its isoenzymes in the blood formed elements and in the urine of VH patients was of certain diagnostic value but inferior in many respects to its determination in the blood serum.
对850例病毒性肝炎（VH）患者的多种生物介质中的乳酸脱氢酶（LDH）及其同工酶活性进行了研究。VH患者血清、血液有形成分及尿液中LDH及其同工酶LDH5的活性，在病情严重及抗原阳性的VH患者中变化更为明显。重症VH患者血清中LDH及LDH5活性急剧升高，随后显著下降，提示急性肝坏死的发生。VH患者血液有形成分中LDH及其同工酶活性的变化表明能量系统紊乱，影响其形态和功能状态。患者尿液中LDH及其同工酶的变化提示肾脏病变，可用于检测VH患者潜在的肾功能障碍。研究VH患者血液有形成分及尿液中LDH及其同工酶的活性具有一定的诊断价值，但在许多方面不如血清中的测定。
