用于现场邻苯二酚分析的简单、快速且可视化的电化学发光传感器。
Simple, rapid, and visual electrochemiluminescence sensor for on-site catechol analysis.
作者信息
Chen Suhua, Lei Yuanyuan, Xu Junrong, Yang Yun, Dong Yiying, Li Yanmei, Yi Haomin, Liao Yilong, Chen Liyin, Xiao Yi
机构信息
Hunan Provincial Maternal and Child Health Care Hospital Changsha 410008 Hunan China
Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy, School of Medicine, Hunan Normal University Changsha 410013 Hunan China.
出版信息
RSC Adv. 2022 Jun 13;12(27):17330-17336. doi: 10.1039/d2ra03067e. eCollection 2022 Jun 7.
Environmental pollution caused by aromatic compounds such as catechol (Cat) has become a major issue for human health. However, there is no simple, rapid, and low-cost method for on-site monitoring of Cat. Here, based on ECL quenching mechanism, we develop a simple, rapid and visual mesoporous silica (MSNs)-electrochemiluminescence (ECL) sensor for on-site monitoring of Cat. The mechanism of ECL quenching is due to the interaction between Cat and Ru(bpy) and the interactions between the oxidation products of Cat and DBAE. MSNs films with ordered perpendicular mesopore channels exhibit an amplification effect of ECL intensity due to the negatively charged pore channel. There is a good linear relationship between ECL intensity and Cat concentration in the range of 10 ∼ 1000 μM with the limit of detection (LOD) of 9.518 μM ( = 0.99). The on-site sensor is promising to offer new opportunities for pharmaceuticals analysis, on-site monitoring, and exposure risk assessment.
由邻苯二酚（Cat）等芳香族化合物引起的环境污染已成为影响人类健康的主要问题。然而，目前尚无用于现场监测Cat的简单、快速且低成本的方法。在此，基于电化学发光（ECL）猝灭机制，我们开发了一种用于现场监测Cat的简单、快速且可视化的介孔二氧化硅（MSNs）-电化学发光（ECL）传感器。ECL猝灭的机制是由于Cat与Ru(bpy)之间的相互作用以及Cat的氧化产物与二丁胺乙氧基乙醇（DBAE）之间的相互作用。具有有序垂直介孔通道的MSNs膜由于带负电荷的孔道而表现出ECL强度的放大效应。在10 ∼ 1000 μM范围内，ECL强度与Cat浓度之间存在良好的线性关系，检测限（LOD）为9.518 μM（ = 0.99）。这种现场传感器有望为药物分析、现场监测和暴露风险评估提供新的机会。
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