SeyedAlinaghi SeyedAhmad, Karimi Amirali, Pashaei Zahra, Afzalian Arian, Mirzapour Pegah, Ghorbanzadeh Kobra, Ghasemzadeh Afsaneh, Dashti Mohsen, Nazarian Newsha, Vahedi Farzin, Tantuoyir Marcarious M, Shamsabadi Ahmadreza, Dadras Omid, Mehraeen Esmaeil
Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Arch Acad Emerg Med. 2022 May 22;10(1):e41. doi: 10.22037/aaem.v10i1.1597. eCollection 2022.
Knowledge of vaccine-related adverse events is crucial as they are among the most important factors that cause hesitation in receiving vaccines. Therefore, we aimed to systematically review the adverse events related to the mRNA vaccines reported in the literature..
A systematic literature search was carried out in the databases of Scopus, PubMed, Cochrane, and Web of Science. We selected original studies that explored the side effects of mRNA COVID-19 vaccines using a two-phase (title/abstract and full-text) screening process..
Cardiac complications were the most commonly reported severe adverse events. It appeared that systemic adverse reactions are more common after the second dose of vaccines. The number of adverse effects reported after the Pfizer vaccine was higher than other vaccines, mostly due to its earlier approval and more widespread use throughout the world. Cardiac adverse events had a higher prevalence but no significant association has been found between COVID-19 mRNA vaccines and cardiac adverse events except for myopericarditis. .
Vaccines play a crucial role in controlling the COVID-19 pandemic and decreasing mortalities and the results of the present review acknowledge the fact that the benefits outweigh the adverse events of these vaccines..
了解疫苗相关不良事件至关重要，因为它们是导致人们对接种疫苗犹豫不决的最重要因素之一。因此，我们旨在系统回顾文献中报道的与mRNA疫苗相关的不良事件。
在Scopus、PubMed、Cochrane和科学网数据库中进行了系统的文献检索。我们通过两阶段（标题/摘要和全文）筛选过程，选择了探索mRNA新冠疫苗副作用的原始研究。
心脏并发症是最常报告的严重不良事件。似乎全身不良反应在第二剂疫苗接种后更为常见。辉瑞疫苗接种后报告的不良反应数量高于其他疫苗，这主要是由于其获批时间较早且在全球范围内使用更为广泛。心脏不良事件的发生率较高，但除了心肌心包炎外，未发现新冠mRNA疫苗与心脏不良事件之间存在显著关联。
疫苗在控制新冠疫情和降低死亡率方面发挥着关键作用，本综述结果认可了这些疫苗的益处大于不良事件这一事实。
