Abdolmohammadi Pouria, Bietar Bashir, Zhou Juan, Lehmann Christian
Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B2H 0A3, Canada.
Department of Pharmacology, Dalhousie University, Halifax, NS B2H 0A3, Canada.
Molecules. 2025 Jun 28;30(13):2795. doi: 10.3390/molecules30132795.
Ischemic stroke, responsible for the majority of stroke cases worldwide, triggers profound neuroinflammatory responses largely mediated by microglia. Excessive activation of pro-inflammatory microglia exacerbates neuronal injury, highlighting the need for therapeutic strategies targeting microglial modulation. Propofol (2,6-diisopropylphenol), a widely used intravenous anesthetic, has emerged as a promising neuroprotective agent due to its potent anti-inflammatory properties. This review comprehensively explores the diverse cellular mechanisms by which propofol attenuates microglial activation and inflammation in ischemic stroke. By elucidating these molecular pathways, it underscores the therapeutic potential of propofol in mitigating ischemic brain injury and guiding future clinical interventions.
缺血性中风是全球大多数中风病例的病因，它引发了主要由小胶质细胞介导的深刻神经炎症反应。促炎性小胶质细胞的过度激活会加剧神经元损伤，这凸显了针对小胶质细胞调节的治疗策略的必要性。丙泊酚（2,6-二异丙基苯酚）是一种广泛使用的静脉麻醉剂，由于其强大的抗炎特性，已成为一种有前景的神经保护剂。这篇综述全面探讨了丙泊酚减轻缺血性中风中小胶质细胞激活和炎症的多种细胞机制。通过阐明这些分子途径，它强调了丙泊酚在减轻缺血性脑损伤方面的治疗潜力，并为未来的临床干预提供指导。
