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测定牛奶、豆浆和肠内营养补充剂中的总嘌呤和游离嘌呤含量,以辅助高尿酸血症和痛风的营养治疗。

Determination of total purine and free purine content in milk, soymilk, and enteral nutritional supplements to assist nutritional therapy for hyperuricemia and gout.

作者信息

Fukuuchi Tomoko, Itahashi Itsuki, Takayanagi Fukue, Yamaoka Noriko, Kaneko Kiyoko

机构信息

Laboratory of Biomedical and Analytical Sciences, Faculty of Pharma-Science, Teikyo University, Tokyo, Japan.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2022;41(12):1287-1295. doi: 10.1080/15257770.2022.2093362. Epub 2022 Jun 29.

DOI:10.1080/15257770.2022.2093362
PMID:35767334
Abstract

In this study, we determined the purine contents in milk and soymilk, as protein-rich drinks, and in enteral nutritional supplements employed to ameliorate protein malnutrition in the elderly. Milk consumption is known to lower serum uric acid levels and to promote uric acid excretion. However, discrepant results have been reported regarding the effect of soymilk on serum uric acid levels. The purpose of this study was to quantify and compare the total purine contents and the contents of individual purines and pyrimidines by molecular type (nucleotides, nucleosides, and bases).

摘要

在本研究中,我们测定了作为富含蛋白质饮品的牛奶和豆浆以及用于改善老年人蛋白质营养不良的肠内营养补充剂中的嘌呤含量。众所周知,饮用牛奶可降低血清尿酸水平并促进尿酸排泄。然而,关于豆浆对血清尿酸水平的影响,已有相互矛盾的报道。本研究的目的是按分子类型(核苷酸、核苷和碱基)对总嘌呤含量以及单个嘌呤和嘧啶的含量进行定量和比较。

相似文献

1
Determination of total purine and free purine content in milk, soymilk, and enteral nutritional supplements to assist nutritional therapy for hyperuricemia and gout.测定牛奶、豆浆和肠内营养补充剂中的总嘌呤和游离嘌呤含量,以辅助高尿酸血症和痛风的营养治疗。
Nucleosides Nucleotides Nucleic Acids. 2022;41(12):1287-1295. doi: 10.1080/15257770.2022.2093362. Epub 2022 Jun 29.
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Purine content of hospital meals and its effect on serum uric acid, urine pH, and urinary uric acid excretion.医院膳食的嘌呤含量及其对血清尿酸、尿液pH值和尿尿酸排泄的影响。
Nucleosides Nucleotides Nucleic Acids. 2022;41(12):1296-1304. doi: 10.1080/15257770.2022.2106492. Epub 2022 Aug 3.
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Total purine and purine base content of common foodstuffs for facilitating nutritional therapy for gout and hyperuricemia.常见食物的总嘌呤和嘌呤碱含量,以促进痛风和高尿酸血症的营养治疗。
Biol Pharm Bull. 2014;37(5):709-21. doi: 10.1248/bpb.b13-00967. Epub 2014 Feb 20.
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Determination of total purine and purine base content of 80 food products to aid nutritional therapy for gout and hyperuricemia.测定 80 种食品中的总嘌呤和嘌呤碱基含量,以辅助痛风和高尿酸血症的营养治疗。
Nucleosides Nucleotides Nucleic Acids. 2020;39(10-12):1449-1457. doi: 10.1080/15257770.2020.1748197. Epub 2020 Apr 20.
5
Purine metabolism in women with primary gout.原发性痛风女性的嘌呤代谢
Am J Med. 1994 Oct;97(4):332-8. doi: 10.1016/0002-9343(94)90299-2.
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Influence of purine intake on uric acid excretion in infants fed soy infant formulas.嘌呤摄入量对食用大豆婴儿配方奶粉的婴儿尿酸排泄的影响。
J Am Coll Nutr. 2000 Feb;19(1):16-22. doi: 10.1080/07315724.2000.10718909.
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Hereditary nephropathy associated with hyperuricemia and gout.与高尿酸血症和痛风相关的遗传性肾病。
Arch Intern Med. 1993 Feb 8;153(3):357-65.
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A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response.一项针对嘌呤代谢物的果蝇全基因组关联研究鉴定出人类 FAM214 同源物 Medusa,它以保守的方式通过调节嘌呤代谢和炎症反应来增强高尿酸血症驱动的病理。
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[Hyperuricemia and disorders in content of amino acids-purine precursors in patients with autoimmune diseases and gout].[自身免疫性疾病和痛风患者的高尿酸血症及氨基酸-嘌呤前体含量紊乱]
Lik Sprava. 2005 Jun(4):34-6.
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Changes in purine and uric acid content in edible insects during culinary processing.烹饪加工过程中食用昆虫中嘌呤和尿酸含量的变化。
Food Chem. 2023 Mar 1;403:134349. doi: 10.1016/j.foodchem.2022.134349. Epub 2022 Sep 21.

引用本文的文献

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Effect on consumers' sustainable purchase intention of dietary supplement purine labeling.膳食补充剂嘌呤标签对消费者可持续购买意愿的影响。
Front Nutr. 2025 Jun 4;12:1526713. doi: 10.3389/fnut.2025.1526713. eCollection 2025.
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Daily Amount of Purine in Commonly Recommended Well-Balanced Diets in Japan and Overseas.日本及海外常见的均衡饮食中嘌呤的每日摄入量。
Nutrients. 2024 Nov 27;16(23):4066. doi: 10.3390/nu16234066.
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The Association of Food Groups and Consumption Time with Hyperuricemia: The U.S. National Health and Nutrition Examination Survey, 2005-2018.
食物组和摄食时间与高尿酸血症的关联:美国 2005-2018 年国家健康与营养调查。
Nutrients. 2023 Jul 12;15(14):3109. doi: 10.3390/nu15143109.