School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019, P. R. China.
Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
Inorg Chem. 2023 Feb 6;62(5):1786-1790. doi: 10.1021/acs.inorgchem.2c01206. Epub 2022 Jun 29.
Supramolecular coordination complexes formed by coordination-induced assembly not only avoid the loss of activity of precursors but also provide an efficient way for controlled release, which can be further used in various fields of biology such as drug delivery, cell imaging, and tumor treatment. In this work, a Pt metallaclip () was prepared from 4-[4-(1,2,2-triphenylvinyl)phenyl]pyridine (), 5,10,15-triphenyl-20-(pyridin-4-yl)porphyrin (), , and glycol-chain-modified isophthalic acid () in an acetone/water mixture through the "coordination-driven self-assembly" method. P and H NMR spectroscopy and high-resolution mass spectrometry were used to characterize the obtained metallaclip . can self-assemble into fluorescent nanostructures in aqueous solution because of the tetraphenylethylene unit and its amphiphilic nature. Importantly, the fluorescent nanoparticles not only can be employed for cell imaging but also can generate singlet oxygen (O) under 660 nm laser irradiation and the release of drug in the tumor issue for cancer therapy. The work may provide a new way for scientists to construct functional biomaterials with multiple applications via molecular self-assembly.
由配位诱导组装形成的超分子配位配合物不仅避免了前体活性的丧失，而且为控制释放提供了一种有效途径，可进一步用于药物输送、细胞成像和肿瘤治疗等生物学的各个领域。在这项工作中，通过“配位驱动自组装”法，在丙酮/水混合物中，由 4-[4-(1,2,2-三苯基乙烯基)苯基]吡啶()、5,10,15-三苯基-20-(吡啶-4-基)卟啉()、 和乙二醇链修饰的间苯二甲酸()制备了 Pt 金属夹()。使用 P 和 H NMR 光谱和高分辨率质谱对所得金属夹进行了表征。由于四苯乙烯单元及其两亲性，在水溶液中可以自组装成荧光纳米结构。重要的是，荧光纳米粒子不仅可以用于细胞成像，而且可以在 660nm 激光照射下产生单线态氧(O)和肿瘤组织中药物的释放，用于癌症治疗。这项工作可能为科学家通过分子自组装构建具有多种应用的功能性生物材料提供了一种新方法。
