School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019, P.R. China.
Inorg Chem. 2021 Jun 7;60(11):7627-7631. doi: 10.1021/acs.inorgchem.1c00962. Epub 2021 May 11.
The development of the supramolecular coordination complex with different shapes and dimensionalities lays the basis for its application in different areas. In this study, a porphyrin-based 3D organo-Pt(II) metallatriangle () was fabricated through the reported method termed as "coordination driven self-assembly". P NMR, H NMR, HR-MS, and theoretical calculation were employed to characterize the resultant fully. Furthermore, the fabricated nanocomposite through coassembly of and an amphiphilic polypeptide () could generate singlet oxygen (O) under the NIR irradiation and release a Pt drug under a low-pH microenvironment. O and the Pt drug can both damage the cancer cells, which improves the efficiency of cancer therapies. The fabrication of a Pt-porphyrin metallatriangle expands the topological structures, and the Pt-porphyrin metallatriangle can be applied to the combined cancer therapies. Moreover, various stimuli-responsive groups can be modified to the triangle, so a new method is created to develop high-performance biosupramolecular materials.
具有不同形状和维度的超分子配位化合物的发展为其在不同领域的应用奠定了基础。在这项研究中，通过报道的称为“配位驱动自组装”的方法制备了基于卟啉的 3D 有机-Pt(II)金属三角体（）。通过 P NMR、H NMR、HR-MS 和理论计算对所得的 进行了充分表征。此外，通过 和两亲多肽（）的共组装制备的纳米复合材料可以在近红外辐射下产生单线态氧（O），并在低 pH 微环境下释放 Pt 药物。O 和 Pt 药物都可以破坏癌细胞，从而提高癌症治疗的效率。Pt-卟啉金属三角体的构建扩展了拓扑结构，并且 Pt-卟啉金属三角体可应用于联合癌症治疗。此外，各种刺激响应基团可以修饰到三角形上，因此为开发高性能生物超分子材料创造了一种新方法。
