Department of Gynecological Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, People's Republic of China.
Department of Gynecological Oncology, Nanhai Maternal and Child Heath Hospital, Guiping West Road, Guicheng, Nanhai District, Foshan, 528200, China.
BMC Womens Health. 2022 Jun 29;22(1):264. doi: 10.1186/s12905-022-01850-7.
Endometriosis is a common and challenging disease in women of childbearing age with high personal and social costs. Many molecular differences between ectopic and eutopic endometrium present difficulties in the development of new drug therapies and therapies. Autophagy is a response to stress and has recently been studied in human cancers. Two important autophagy genes, Beclin-1 and LC3, have been reported in several human cancers. However, the reports of Beclin-1 and LC3 in endometriosis are limited and controversial.
In this study, we investigated the expression of Beclin-1 and LC3 by Immunohistochemistry.
We found their downregulation in endometriosis. We also found these two autophagy gene expression are negatively correlated with the stage of endometriosis.
Decreased expression of Beclin-1 and LC3 may be related to the occurrence and development of endometriosis.
子宫内膜异位症是一种常见且具有挑战性的疾病，好发于育龄期妇女，给个人和社会带来沉重负担。异位和在位子宫内膜之间存在许多分子差异，这给新的药物治疗和疗法的发展带来了困难。自噬是一种应激反应，最近在人类癌症中进行了研究。两个重要的自噬基因 Beclin-1 和 LC3 在几种人类癌症中已有报道。然而，关于子宫内膜异位症中 Beclin-1 和 LC3 的报道有限且存在争议。
本研究采用免疫组织化学法检测 Beclin-1 和 LC3 的表达。
我们发现它们在子宫内膜异位症中表达下调。我们还发现这两种自噬基因的表达与子宫内膜异位症的分期呈负相关。
Beclin-1 和 LC3 的表达下调可能与子宫内膜异位症的发生和发展有关。
