[Profiles of serological markers of HBV-infection in acute hepatitis B].

The authors demonstrate that severe and fulminant forms of acute hepatitis B (AHB) are associated with low concentrations of HBsAg and anti HBs in peripheral blood. In the majority of cyclic AHB cases HBeAg is registered in the serum for 2-3 weeks, whereas in more severe course of AHB its indication is shorter, with occasional occurrence of serological window. The more severe and longer was AHB course the lower was concentration of HBsAg in peripheral blood. The assessment of the complete profile of serological markers of HBV infection and HBsAg concentration in the serum in the course of the disease will promote more effective diagnosis of the disease pattern and outcome.