Nikiforov N D, Sanin B I, Nikiforova G S, Saiapina E S, Novikova L V, Il'inskii I A, Popov A F
Clinic Hospital of Infectious Diseases N3, Moscow.
Klin Med (Mosk). 1996;74(7):16-8.
The authors demonstrate that severe and fulminant forms of acute hepatitis B (AHB) are associated with low concentrations of HBsAg and anti HBs in peripheral blood. In the majority of cyclic AHB cases HBeAg is registered in the serum for 2-3 weeks, whereas in more severe course of AHB its indication is shorter, with occasional occurrence of serological window. The more severe and longer was AHB course the lower was concentration of HBsAg in peripheral blood. The assessment of the complete profile of serological markers of HBV infection and HBsAg concentration in the serum in the course of the disease will promote more effective diagnosis of the disease pattern and outcome.
作者表明，严重和暴发性急性乙型肝炎（AHB）与外周血中低浓度的乙肝表面抗原（HBsAg）和乙肝表面抗体（抗-HBs）有关。在大多数周期性AHB病例中，e抗原（HBeAg）在血清中持续2至3周，而在更严重的AHB病程中，其显示时间较短，偶尔会出现血清学窗口期。AHB病程越严重、越长，外周血中HBsAg的浓度就越低。评估HBV感染血清学标志物的完整谱以及疾病过程中血清中的HBsAg浓度，将有助于更有效地诊断疾病模式和预后。
