Badri Shirinsadat, Vahdat Sahar, Pourfarzam Morteza, Assarzadeh Samaneh, Seirafian Shiva, Ataei Sara
Department of Clinical Pharmacy and Pharmacy Practice, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Pharm Pract. 2022 May 25;10(4):149-158. doi: 10.4103/jrpp.jrpp_3_22. eCollection 2021 Oct-Dec.
Trace element deficiency is common among patients with end-stage renal disease (ESRD); the reason is that since these patients undergo dialysis, they lose these elements more than healthy people, and also the use of trace elements is restricted due to loss of appetite. Selenium (Se) is a trace element that is essential for the oxidative stress defense system. Se deficiency leads to some complications similar to those often seen in ESRD patients, such as all-cause mortality due to cardiovascular diseases, bone loss, uric acid elevation, and anemia. This article aims to review the evidence on consequences of Se deficiency in ESRD patients, as well as effects of Se supplementation in hemodialysis patients. Multiple databases were searched to summarize the available evidence on selenium's role in kidney diseases. Since the complications of ESRD and those of Se deficiency are mostly similar, this triggers the idea that Se deficiency may be considered as a cause of these problems, but it needs to be more assessed that Se deficiency is a single factor or there are other factors participated in. Also the role of Se supplementation on resolving the mentioned complications, needs to be more studied through welldesigned clinical studies.
微量元素缺乏在终末期肾病（ESRD）患者中很常见；原因在于这些患者接受透析，他们比健康人更多地流失这些元素，而且由于食欲不振，微量元素的摄入也受到限制。硒（Se）是氧化应激防御系统必需的一种微量元素。硒缺乏会导致一些与ESRD患者常见并发症相似的情况，如心血管疾病导致的全因死亡率、骨质流失、尿酸升高和贫血。本文旨在综述ESRD患者硒缺乏后果的证据，以及硒补充剂对血液透析患者的影响。检索了多个数据库以总结关于硒在肾脏疾病中作用的现有证据。由于ESRD的并发症与硒缺乏的并发症大多相似，这引发了一种观点，即硒缺乏可能被视为这些问题的一个原因，但需要更多评估硒缺乏是单一因素还是有其他因素参与其中。此外，硒补充剂在解决上述并发症方面的作用，需要通过精心设计的临床研究进行更多的研究。
