Kiss István
Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika, Geriátriai Tanszéki Csoport Budapest Szent Imre Oktató Kórház Nephrologia-Hypertonia Profil Budapest B. Braun Avitum Dialízis Hálózat 1. sz. Dialízisközpont Budapest Halmi u. 20-22. 1115.
Orv Hetil. 2013 Oct 13;154(41):1641-7. doi: 10.1556/OH.2013.29733.
Selenium is an essential trace element for the human body with a significant antioxidant effect. Selenium deficiency and excess are both detrimental for proper functioning of the human body. The possible association between selenium deficiency and acute or chronic renal disease, along with their complications has been less intensively investigated, however, there are firm data showing that selenium deficiency and renal failure increase the risk of both coronary artery disease and total mortality. Further studies revealed that selenium deficiency increases the risk of death due to infection in patients treated with hemodialysis through dysfunction of the immune system. However, there are no data whether the imbalance of selenium metabolism, especially selenium deficiency, could cause chronic kidney disease or renal failure. As far as results of selenium measurements, there is convincing evidence that protein loss and renal replacement treatment reduce serum selenium levels. Despite some contradictory results obtained from various studies regarding selenium deficiency in chronic kidney diseases, it seems that selenium supplementation may be beneficial in many patients with severe or end-stage kidney disease including those treated with dialysis.
硒是人体必需的微量元素，具有显著的抗氧化作用。硒缺乏和过量对人体正常功能均有害。硒缺乏与急性或慢性肾脏疾病及其并发症之间的可能关联研究较少，然而，有确凿数据表明，硒缺乏和肾衰竭会增加冠状动脉疾病和全因死亡率的风险。进一步研究表明，硒缺乏会通过免疫系统功能障碍增加接受血液透析治疗患者因感染导致的死亡风险。然而，尚无数据表明硒代谢失衡，尤其是硒缺乏，是否会导致慢性肾脏病或肾衰竭。就硒测量结果而言，有令人信服的证据表明蛋白质丢失和肾脏替代治疗会降低血清硒水平。尽管关于慢性肾脏病中硒缺乏的各种研究得出了一些相互矛盾的结果，但似乎补充硒可能对许多重症或终末期肾病患者有益，包括接受透析治疗的患者。
