Ren Bingbing, Su Hua, Bao Chang, Xu Hangdi, Xiao Ying
Department of Pulmonary and Critical Care Medicine, Regional Medical Center for National Institute of Respiratory Disease, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.
Central Lab of Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310020, Zhejiang, China.
Noncoding RNA Res. 2024 Jun 4;9(4):1111-1119. doi: 10.1016/j.ncrna.2024.06.005. eCollection 2024 Dec.
Chronic obstructive pulmonary disease (COPD) is the most prevalent chronic respiratory disorder that is becoming the leading cause of morbidity and mortality on a global scale. There is an unmet need to investigate the underlying pathophysiological mechanisms and unlock novel therapeutic avenues for COPD. Recent research has shed light on the significant roles played by diverse noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), in orchestrating the development and progression of COPD. This review provides an overview of the regulatory roles of ncRNAs in COPD, elucidating their underlying mechanisms, and illuminating the potential prospects of RNA-based therapeutics in the management of COPD.
慢性阻塞性肺疾病（COPD）是最常见的慢性呼吸系统疾病，正成为全球发病和死亡的主要原因。对于研究COPD潜在的病理生理机制并开辟新的治疗途径，仍存在未被满足的需求。最近的研究揭示了多种非编码RNA（ncRNA），包括微小RNA（miRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA），在COPD的发生发展过程中所起的重要作用。本综述概述了ncRNA在COPD中的调控作用，阐明了其潜在机制，并阐述了基于RNA的疗法在COPD治疗中的潜在前景。
