Lu Jingwei, Jiang Li, Chen Yixuan, Lyu Kexin, Zhu Bin, Li Yujie, Liu Xueli, Liu Xinyue, Long Longhai, Wang Xiaoqiang, Xu Houping, Wang Dingxuan, Li Sen
School of Physical Education, Southwest Medical University, Luzhou, China.
The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Front Physiol. 2022 Jun 13;13:852795. doi: 10.3389/fphys.2022.852795. eCollection 2022.
Tendon injury is a disorder of the musculoskeletal system caused by overuse or trauma, which is characterized by pain and limitations in joint function. Since tendon healing is slowly and various treatments are generally ineffective, it remains a clinically challenging problem. Recent evidences suggest that basic fibroblast growth factor (bFGF) not only plays an important role in tendon healing, but also shows a positive effect in laboratory experimentations. The purpose of this review is to summarize the effects of bFGF in the tendon healing. Firstly, during the inflammatory phase, bFGF stimulates the proliferation and differentiation of vascular endothelial cells to foster neovascularization. Furthermore, bFGF enhances the production of pro-inflammatory factors during the early phase of tendon healing, thereby accelerating the inflammatory response. Secondly, the cell proliferation phase is accompanied by the synthesis of a large number of extracellular matrix components. bFGF speeds up tendon healing by stimulating fibroblasts to secrete type III collagen. Lastly, the remodeling phase is characterized by the transition from type III collagen to type I collagen, which can be promoted by bFGF. However, excessive injection of bFGF can cause tendon adhesions as well as scar tissue formation. In future studies, we need to explore further applications of bFGF in the tendon healing process.
肌腱损伤是一种由过度使用或创伤引起的肌肉骨骼系统疾病，其特征为疼痛和关节功能受限。由于肌腱愈合缓慢且各种治疗通常无效，它仍然是一个具有临床挑战性的问题。最近的证据表明，碱性成纤维细胞生长因子（bFGF）不仅在肌腱愈合中起重要作用，而且在实验室实验中也显示出积极效果。本综述的目的是总结bFGF在肌腱愈合中的作用。首先，在炎症阶段，bFGF刺激血管内皮细胞的增殖和分化以促进新血管形成。此外，bFGF在肌腱愈合早期增强促炎因子的产生，从而加速炎症反应。其次，细胞增殖阶段伴随着大量细胞外基质成分的合成。bFGF通过刺激成纤维细胞分泌III型胶原加速肌腱愈合。最后，重塑阶段的特征是从III型胶原向I型胶原的转变，这可由bFGF促进。然而，过量注射bFGF可导致肌腱粘连以及瘢痕组织形成。在未来的研究中，我们需要探索bFGF在肌腱愈合过程中的进一步应用。
