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[实验性脑出血时脑能量代谢的变化]

[Changes in brain energy metabolism in experimental cerebral hemorrhage].

作者信息

Maslov L N

出版信息

Vopr Med Khim. 1987 Jan-Feb;33(1):59-62.

PMID:3577058
Abstract

Intracerebral hemorrhage impaired the functional activity of rat brain mitochondria. After experimental insult the rate of succinate and alpha-ketoglutarate oxidation was decreased at the states 3 and 4 in brain mitochondria as well as in presence of 2,4-dinitrophenol. The rate of phosphorylation was also decreased in oxidation of both NAD- and FAD-dependent substrates.

摘要

脑出血损害了大鼠脑线粒体的功能活性。实验性损伤后，脑线粒体中琥珀酸和α-酮戊二酸的氧化速率在状态3和状态4下以及在2,4-二硝基苯酚存在时均降低。NAD依赖性和FAD依赖性底物氧化时的磷酸化速率也降低。

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