Kerr David, Abbasi Mahsan, Bevier Wendy, Glantz Namino, Larez Arianna, Sabharwal Ashutosh
Sansum Diabetes Research Institute, Santa Barbara, CA, USA.
Electrical and Computer Engineering, Rice University, Houston, TX, USA.
J Diabetes Sci Technol. 2024 Jan;18(1):106-112. doi: 10.1177/19322968221105531. Epub 2022 Jun 30.
Despite the clear benefits of increased physical activity (PA) on glycemic control, little is known about the importance of the timing of exercise among people with diabetes. Our objective was to compare the time of day of PA with concurrent HbA1c levels and body mass index (BMI) among Hispanic/Latino adults with or at risk of type 2 diabetes (T2D).
Monitored activity data obtained from Hispanic/Latino adults were summarized as number of steps per day, moderate-to vigorous-intensity physical activity (MVPA), and energy expenditure (kcals/day). We next examined the association between PA measures and participants' HbA1c. -means clustering analysis was applied to identify daily PA patterns by time of day and intensity.
Three dominant clusters were identified: low-intensity PA, and early and late PA by time of day. The step counts were correlated with HbA1c in the late-active group ( = .01). Furthermore, independently in younger adults (age ≤ 50 years) and in overweight adults 25 ≤ BMI < 30 kg/m), there was an association between HbA1c and step counts ( < .01 and < .005, respectively) as well as HbA1c and MVPA ( < .05 and < .035, respectively).
For Hispanic/Latino adults with or at risk of T2D, there appears to be clustering of PA by intensity and time of day which, in turn, may influence achieved HbA1c and BMI. Our findings demonstrate that the amount of activity is more efficacious on HbA1c in participants who are more active later during the day and separately in overweight and younger individuals. This finding may help design more personalized PA recommendations in this population.
CLINICALTRIALS.GOV IDENTIFIERS: NCT03830840 and NCT03736468.
尽管增加身体活动（PA）对血糖控制有明显益处，但对于糖尿病患者运动时间的重要性却知之甚少。我们的目标是比较西班牙裔/拉丁裔2型糖尿病（T2D）患者或有T2D风险的成年人一天中进行PA的时间与同期糖化血红蛋白（HbA1c）水平和体重指数（BMI）之间的关系。
从西班牙裔/拉丁裔成年人中获取的监测活动数据总结为每日步数、中等至剧烈强度身体活动（MVPA）和能量消耗（千卡/天）。接下来，我们研究了PA指标与参与者HbA1c之间的关联。采用均值聚类分析按时间和强度确定每日PA模式。
确定了三个主要类别：低强度PA，以及按时间划分的早晚PA。在晚活跃组中，步数与HbA1c相关（r = 0.01）。此外，在年龄≤50岁的年轻成年人以及超重成年人（25≤BMI<30kg/m²）中，HbA1c与步数之间存在关联（分别为P<0.01和P<0.005），HbA1c与MVPA之间也存在关联（分别为P<0.05和P<0.035）。
对于患有T2D或有T2D风险的西班牙裔/拉丁裔成年人，PA似乎按强度和时间聚类，这反过来可能会影响所达到的HbA1c和BMI。我们的研究结果表明，在一天中较晚时段更活跃的参与者以及超重和年轻个体中，活动量对HbA1c的影响更显著。这一发现可能有助于为该人群设计更个性化的PA建议。
NCT03830840和NCT03736468。
