Lemberger L
Xenobiotica. 1987 Mar;17(3):267-73. doi: 10.3109/00498258709043937.
The development of new drugs as potential therapeutic agents involves multi-discipline 'team' research. The clinician has to deal with scientific and ethical issues and keep in mind the axiom 'Primum no nocere--Above all, do no harm.' The clinical pharmacologist has to address the pharmacologic actions of a potential new drug and if any antidotes are available. Species in pharmacologic actions, assessment of animal laboratory data to determine the sensitive organs, and the role of drug metabolism in evaluating and correlating animal data all need to be addressed. The clinical pharmacologist has an important role in new drug development which is unique and includes the responsibility to ensure the welfare of the volunteer subjects or patients.
开发新型药物作为潜在治疗剂涉及多学科“团队”研究。临床医生必须处理科学和伦理问题，并牢记“首要的是不伤害——最重要的是，不要造成伤害”这一准则。临床药理学家必须研究潜在新药的药理作用以及是否有任何解毒剂。药理作用的物种差异、评估动物实验室数据以确定敏感器官以及药物代谢在评估和关联动物数据中的作用都需要加以研究。临床药理学家在新药开发中具有独特而重要的作用，包括有责任确保志愿者受试者或患者的福祉。
