Faculty of Medicine and Health Science, Department of Human Structure and Repair, Ghent University, Belgium.
Department of Cardiology, Ghent University Hospital, Belgium.
Prog Urol. 2022 Sep;32(11):756-762. doi: 10.1016/j.purol.2022.05.005. Epub 2022 Jun 27.
Nocturia is frequent among older patients and has been linked to cardiovascular diseases. The aim of this study was to assess the time relationship between the onset of nocturia and coronary heart disease (CHD). Specifically, this study investigated whether nocturia can be identified as a red flag de novo symptom in patients with CHD.
This cross-sectional study consisted of patients with CHD-related cardiac complaints who were prospectively recruited from November 2019 till March 2020 at the cardiac catheterization laboratory of the Ghent University Hospital. An analysis was performed to determine the time relationship between nocturia and CHD and to describe the nocturia characteristics.
Forty-five patients with nocturia and established CHD were included. Of these patients, 74% (31/42) developed nocturia before their cardiac symptoms occurred, with a median time gap of 57 months (IQR 19-101). Furthermore, 64% (29/45) of them had clinically significant nocturia (≥2 nocturnal voids) and there was a significant correlation between age at which nocturia and cardiac symptoms occurred (r=0.89, p<0.001).
This is the first study that analysed the time relationship between onset of nocturia and onset of cardiac complaints in patients with CHD. In most of the patients, nocturia had started before they were diagnosed with CHD, meaning that nocturia might precede the development of cardiac symptoms, such as angina and shortness of breath. Keeping this in mind, de novo nocturia may or even should be considered as a red flag for CHD.
4: (cross sectional study with prospectively recruitement) Source: https://www.ciap.health.nsw.gov.au/training/ebp-learning-modules/module1/grading-levels-of-evidence.html.
夜尿症在老年患者中较为常见，并与心血管疾病有关。本研究旨在评估夜尿症与冠心病（CHD）发病之间的时间关系。具体而言，本研究调查了夜尿症是否可以作为 CHD 患者新出现的警示症状。
这项横断面研究纳入了 2019 年 11 月至 2020 年 3 月期间在根特大学医院心脏导管室前瞻性招募的 CHD 相关心脏不适患者。进行了一项分析，以确定夜尿症与 CHD 之间的时间关系，并描述夜尿症的特征。
纳入了 45 例有夜尿症且确诊为 CHD 的患者。其中，74%（31/42）在出现心脏症状之前出现夜尿症，中位时间间隔为 57 个月（IQR 19-101）。此外，64%（29/45）的患者存在临床显著的夜尿症（≥2 次夜间排尿），且夜尿症和心脏症状发生的年龄之间存在显著相关性（r=0.89，p<0.001）。
这是第一项分析 CHD 患者夜尿症发病与心脏症状发病之间时间关系的研究。在大多数患者中，夜尿症在被诊断为 CHD 之前就已经出现，这意味着夜尿症可能先于心绞痛和呼吸急促等心脏症状的发展。考虑到这一点，新出现的夜尿症可能是也可能不是 CHD 的警示信号。
4 级：（前瞻性招募的横断面研究）资料来源：https://www.ciap.health.nsw.gov.au/training/ebp-learning-modules/module1/grading-levels-of-evidence.html。
