Kim Junhyung, Hwang Kihwan, Kwon Hyun Jung, Lee Ji Eun, Lee Kyu Sang, Choe Gheeyoung, Han Jung Ho, Kim Chae-Yong
Department of Neurosurgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.
Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.
Front Oncol. 2022 Jun 13;12:885155. doi: 10.3389/fonc.2022.885155. eCollection 2022.
Grade 2/3 meningiomas have locally aggressive behaviors often requiring additional treatment plans after surgical resection. Herein, we explored the clinical significance of next-generation sequencing (NGS) in characterizing the molecular profiles of high-grade meningiomas.
Patients with intracranial meningioma who underwent surgical resection in a single institution were retrospectively reviewed. Clinicopathologic relevance was evaluated using recurrence-free survival (RFS) as an outcome measure. NGS for the targeted gene regions was performed in 40 participants.
Among the 713 individuals in the study population, 143 cases (20.1%) were identified as having grade 2 or 3 meningiomas with a significantly lower female predominance. While the difference in RFS between grade 2 and 3 meningiomas was insignificant, a few conventional grade 2 cases, but with promoter hotspot mutation, were highly progressive and refractory to the treatment. From the NGS study, recurrent mutations in and were identified with a higher prevalence (17.5% and 12.5%, respectively) compared with grade 2/3 meningiomas reported in previous literature. However, their relations to other histopathologic properties or clinical factors were rarely observed.
Grade 2/3 meningiomas show a broad spectrum of molecular profiles, as they have heterogeneous histologic characteristics.
2/3级脑膜瘤具有局部侵袭性，手术切除后常需要额外的治疗方案。在此，我们探讨了二代测序（NGS）在表征高级别脑膜瘤分子特征方面的临床意义。
对在单一机构接受手术切除的颅内脑膜瘤患者进行回顾性研究。以无复发生存期（RFS）作为结局指标评估临床病理相关性。对40名参与者进行靶向基因区域的NGS检测。
在研究人群的713例个体中，143例（20.1%）被确定为2级或3级脑膜瘤，女性优势明显降低。虽然2级和3级脑膜瘤之间的RFS差异不显著，但一些传统的2级病例，具有启动子热点突变，具有高度侵袭性且对治疗难治。从NGS研究中，与先前文献报道的2/3级脑膜瘤相比， 和 的复发突变发生率更高（分别为17.5%和12.5%）。然而，它们与其他组织病理学特征或临床因素的关系很少被观察到。
2/3级脑膜瘤表现出广泛的分子特征谱，因为它们具有异质性组织学特征。
