Sudakov K V
Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 Jan-Feb;37(1):78-87.
Data are presented, demonstrating the action of a number of oligopeptides on biological motivations of hunger, fear, self-stimulation and on alcohol addiction. In the structure of animals feeding motivation, such oligopeptides take part as beta-lipotropin and its fragments, ACTH, pentagastrin, delta-sleep inducing peptide (DSIP), substance P; in organization of defensive motivation--angiotensin II (AII), DSIP, substance P, bradykinin, beta-endorphin etc.; in organization of self-stimulation--AII, DSIP, bradykinin, ACTH, beta-endorphin etc. It is established that most of the above oligopeptides, injected to the brain lateral ventriculi, inhibit biological motivations, and only some of them have an activating action. On the basis of experiments, a hypothesis is formulated that oligopeptides act as a feedback between the genome of brain neurones and pacemaker cells of motivation centres of the hypothalamus area. Some oligopeptides elaborated by neuronal genomes under the action of dominating motivation, activate--and the other--suppress the activity of motivation hypothalamus centres.
文中呈现的数据表明了多种寡肽对饥饿、恐惧、自我刺激等生物动机以及酒精成瘾的作用。在动物进食动机的构成中，诸如β-促脂素及其片段、促肾上腺皮质激素、五肽胃泌素、δ-睡眠诱导肽（DSIP）、P物质等寡肽参与其中；在防御动机的构成中——血管紧张素II（AII）、DSIP、P物质、缓激肽、β-内啡肽等；在自我刺激的构成中——AII、DSIP、缓激肽、促肾上腺皮质激素、β-内啡肽等。已证实，将上述大多数寡肽注入脑侧脑室会抑制生物动机，只有其中一些具有激活作用。基于实验，提出了一个假说，即寡肽在下丘脑区域动机中心的脑神经元基因组与起搏器细胞之间起反馈作用。在主导动机的作用下，神经元基因组产生的一些寡肽激活——而另一些——抑制动机下丘脑中心的活动。
