Chaudhuri Shalini, Banerjee Sandipan, Chattopadhyay Uddalak, Hussain Syed S
Department of Anaesthesiology, Critical Care and Pain, Homi Bhabha Cancer Hospital/Mahamana Pandit Madan Mohan Malviya Cancer Centre, Varanasi, Uttar Pradesh, India.
Indian J Anaesth. 2022 May;66(Suppl 3):S161-S168. doi: 10.4103/ija.ija_716_21. Epub 2022 May 17.
End-tidal anaesthetic gas concentration (ETAG) and bispectral index (BIS) are both used to monitor depth of anaesthesia. Maintaining an accurate depth of anaesthesia helps in early post-operative recovery. This study compared the recovery times from sevoflurane-nitrous oxide anaesthesia using ETAG monitoring with BIS monitoring.
Four hundred and two patients undergoing elective surgeries under sevoflurane- nitrous oxide anaesthesia were enroled in this double blinded parallel group prospective randomised trial and allocated into two groups. The depth of anaesthesia was monitored using BIS in BIS group ( = 202) and end-tidal sevoflurane concentration (EtSevo) in ETAG group ( = 200). The time to extubation and recovery were compared between the groups. Parametric, non-parametric and categorical variables were compared using Student's '' test, Wilcoxon's rank sum test and Chi-square test, respectively.
Time to extubation (min) [BIS group - 10, 5; ETAG group - 10, 5 (median, inter-quartile range, IQR), = 0.32] and time to recovery (min) [BIS group - 14, 6; ETAG group - 13.5, 7 (median, IQR), = 0.34] did not differ significantly between the two groups. The EtSevo concentration (vol%) was significantly higher in the BIS group at 5 min [BIS group - 1.2, 0.4; ETAG group - 1.0, 0.4 (median, IQR), < 0.001], 30 min [BIS group - 1.1, 0.4; ETAG group - 1.0, 0.3 (median, IQR), = 0.002] and 120 min [BIS group - 1.11 ± 0.28; ETAG group - 0.96 ± 0.27 (mean ± standard deviation), = 0.014] after induction of anaesthesia.
BIS and ETAG monitoring are associated with comparable recovery profiles. ETAG monitoring is associated with significantly less sevoflurane consumption.
呼气末麻醉气体浓度（ETAG）和脑电双频指数（BIS）均用于监测麻醉深度。维持精确的麻醉深度有助于术后早期恢复。本研究比较了使用ETAG监测与BIS监测时七氟醚 - 氧化亚氮麻醉后的恢复时间。
402例接受七氟醚 - 氧化亚氮麻醉下择期手术的患者纳入了这项双盲平行组前瞻性随机试验，并分为两组。BIS组（n = 202）使用BIS监测麻醉深度，ETAG组（n = 200）使用呼气末七氟醚浓度（EtSevo）监测。比较两组之间的拔管时间和恢复时间。分别使用学生t检验、威尔科克森秩和检验和卡方检验比较参数、非参数和分类变量。
两组之间的拔管时间（分钟）[BIS组 - 10, 5；ETAG组 - 10, 5（中位数，四分位间距，IQR），P = 0.32]和恢复时间（分钟）[BIS组 - 14, 6；ETAG组 - 13.5, 7（中位数，IQR），P = 0.34]无显著差异。麻醉诱导后5分钟[BIS组 - 1.2, 0.4；ETAG组 - 1.0, 0.4（中位数，IQR），P < 0.001]、30分钟[BIS组 - 1.1, 0.4；ETAG组 - 1.0, 0.3（中位数，IQR），P = 0.002]和120分钟[BIS组 - 1.11 ± 0.28；ETAG组 - 0.96 ± 0.27（均值 ± 标准差），P = 0.014]时，BIS组的EtSevo浓度（体积百分比）显著更高。
BIS和ETAG监测的恢复情况相当。ETAG监测与七氟醚消耗量显著减少相关。
