Immunopathology Group, Mater Research Institute-The University of Queensland, Translational Research Institute, Brisbane, Qld, Australia.
Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Qld, Australia.
Front Cell Infect Microbiol. 2022 Jun 14;12:856962. doi: 10.3389/fcimb.2022.856962. eCollection 2022.
The mucosal surfaces that form the boundary between the external environment and the underlying tissue are protected by a mucus barrier. Mucin glycoproteins, both secreted and cell surface mucins, are the major components of the barrier. They can exclude pathogens and toxins while hosting the commensal bacteria. In this review, we highlight the dynamic function of the mucins and mucus during infection, how this mucosal barrier is regulated, and how pathogens have evolved mechanisms to evade this defence system.
形成外部环境与底层组织之间边界的黏膜表面由黏液屏障保护。黏蛋白糖蛋白，包括分泌型和细胞表面黏蛋白，是屏障的主要成分。它们可以排除病原体和毒素，同时容纳共生细菌。在这篇综述中，我们强调了黏蛋白和黏液在感染过程中的动态功能，黏膜屏障是如何被调节的，以及病原体是如何进化出逃避这种防御系统的机制的。
