Talib Wamidh H, AlHur Mallak J, Al Naimat Sumaiah, Ahmad Rawand E, Al-Yasari Arkan Hadi, Al-Dalaeen Anfal, Thiab Samar, Mahmod Asma Ismail
Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan.
Office of Scientific Affairs and Research, King Hussein Cancer Center, Amman, Jordan.
Front Nutr. 2022 Jun 14;9:905658. doi: 10.3389/fnut.2022.905658. eCollection 2022.
Cancer is one of the leading causes of death worldwide, with almost 10 million cancer-related deaths worldwide in 2020, so any investigation to prevent or cure this disease is very important. Spices have been studied widely in several countries to treat different diseases. However, studies that summarize the potential anticancer effect of spices used in Mediterranean diet are very limited. This review highlighted chemo-therapeutic and chemo-preventive effect of ginger, pepper, rosemary, turmeric, black cumin and clove. Moreover, the mechanisms of action for each one of them were figured out such as anti-angiogenesis, antioxidant, altering signaling pathways, induction of cell apoptosis, and cell cycle arrest, for several types of cancer. The most widely used spice in Mediterranean diet is black pepper ( L). Ginger and black cumin have the highest anticancer activity by targeting multiple cancer hallmarks. Apoptosis induction is the most common pathway activated by different spices in Mediterranean diet to inhibit cancer. Studies discussed in this review may help researchers to design and test new anticancer diets enriched with selected spices that have high activities.
癌症是全球主要死因之一，2020年全球近1000万人死于癌症相关疾病，因此任何预防或治疗这种疾病的研究都非常重要。在多个国家，人们对香料治疗不同疾病进行了广泛研究。然而，总结地中海饮食中使用的香料潜在抗癌作用的研究非常有限。本综述强调了生姜、胡椒、迷迭香、姜黄、黑孜然和丁香的化疗和化学预防作用。此外，还阐明了它们各自针对几种癌症类型的作用机制，如抗血管生成、抗氧化、改变信号通路、诱导细胞凋亡和细胞周期停滞。地中海饮食中使用最广泛的香料是黑胡椒（L）。生姜和黑孜然通过针对多种癌症特征具有最高的抗癌活性。诱导凋亡是地中海饮食中不同香料抑制癌症最常见的激活途径。本综述中讨论的研究可能有助于研究人员设计和测试富含具有高活性的选定香料的新型抗癌饮食。
