Center of Medicinal Chemistry, Dr. André Tosello Avenue, 550, Campinas, SP 13083-886, Brazil.
Laboratory of Design and Synthesis of Bioactive Substances, Department of Pharmacy, University of São Paulo, Prof. Lineu Prestes Avenue 580, Bl.13, Butantã, SP 05508-900, Brazil.
Molecules. 2021 Mar 10;26(6):1521. doi: 10.3390/molecules26061521.
, , and are the main genera of peppers consumed worldwide. The traditional use of peppers by either ancient civilizations or modern societies has raised interest in their biological applications, including cytotoxic and antiproliferative effects. Cellular responses upon treatment with isolated pepper-derived compounds involve mechanisms of cell death, especially through proapoptotic stimuli in tumorigenic cells. In this review, we highlight naturally occurring secondary metabolites of peppers with cytotoxic effects on cancer cell lines. Available mechanisms of cell death, as well as the development of analogues, are also discussed.
、、和 是全球主要的辣椒属食用种。辣椒无论是在古代文明中还是在现代社会中的传统应用，都引起了人们对其生物应用的兴趣，包括细胞毒性和抗增殖作用。用分离的辣椒衍生化合物处理细胞后引起的细胞反应涉及细胞死亡机制，特别是在肿瘤细胞中通过促凋亡刺激。在这篇综述中，我们重点介绍了对癌细胞系具有细胞毒性作用的辣椒天然次生代谢物。还讨论了可用的细胞死亡机制以及类似物的开发。
