Khan Asma A, Mannan Vij, Pervaiz Muhammad Ahad, Akram Aqsa, Momin Elina S, Sanusi Muhammad, Kashyap Tejasvi, Elshaikh Abeer O
College of Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2022 May 27;14(5):e25401. doi: 10.7759/cureus.25401. eCollection 2022 May.
Currently, colorectal cancer is the third most common cancer in the world. Recently, glucosamine and chondroitin have gained popularity for their beneficial effects on cancer. They have already been recognized for their therapeutic role in osteoarthritis. This systematic review aims to analyze the relationship between the combined consumption of glucosamine and chondroitin and the prevention of colorectal cancer. Three databases: PubMed, Google Scholar, and Science Direct, were searched to collect relevant articles. After screening full-text articles, seven studies were included in the systematic review. The review found a supportive association between glucosamine and chondroitin and the decreased incidence of colorectal cancer. Through an anti-inflammatory effect on the cell signaling pathway, the supplementation caused a reduction in colorectal cancer occurrence. The dose, frequency of usage of the supplement, and weight of individuals, along with the use of non-steroidal anti-inflammatory drugs, also affected the efficacy. To further assess this relationship, it is necessary to conduct double-blind, randomized controls trials for the supplements in cancer prevention and further explore their safety and efficacy with different ethnicities, drugs, doses, and weight individuals.
目前，结直肠癌是全球第三大常见癌症。最近，氨基葡萄糖和软骨素因其对癌症的有益作用而受到关注。它们在骨关节炎中的治疗作用已得到认可。本系统评价旨在分析氨基葡萄糖和软骨素联合使用与结直肠癌预防之间的关系。通过检索三个数据库：PubMed、谷歌学术和科学Direct，收集相关文章。在筛选全文文章后，七项研究被纳入该系统评价。该评价发现氨基葡萄糖和软骨素与结直肠癌发病率降低之间存在支持性关联。通过对细胞信号通路的抗炎作用，补充剂导致结直肠癌发生率降低。补充剂的剂量、使用频率、个体体重以及非甾体抗炎药的使用也会影响疗效。为了进一步评估这种关系，有必要对补充剂进行双盲、随机对照试验，以预防癌症，并进一步探索其在不同种族、药物、剂量和体重个体中的安全性和疗效。
