Kai Martine, Matta Christian, Jalkh Georges, Abdallah Youmna, Haddad Fady, Abboud Halim
Department of Internal Medicine and Clinical Immunology, Hôtel-Dieu de France, Faculty of Medicine, Saint Joseph University of Beirut, Beirut, Lebanon.
Department of Neurology, Hôtel-Dieu de France, Faculty of Medicine, Saint Joseph University of Beirut, Beirut, Lebanon.
Eur J Case Rep Intern Med. 2022 May 18;9(5):003377. doi: 10.12890/2022_003377. eCollection 2022.
Multiple sclerosis (MS) is a complex multifactorial disease with different clinical manifestations. Bulbar symptoms such as dysarthria and dysphagia are common in MS patients with advanced secondary progressive disease. However, they are not common at disease onset. We present the case of a 17-year-old male who initially presented with vomiting, dysarthria, and dysphagia. The investigations led to the diagnosis of MS, with an active lesion in the brainstem, more specifically in the area postrema region. Differential diagnoses were eliminated. The patient received intravenous methylprednisolone resulting in amelioration of symptoms. Treatment with fingolimod was started after discharge. The recognition of MS with atypical onsets is important to make an early accurate diagnosis and prescribe appropriate treatment for a disease known to be one of the most common causes of neurologic disability in young adults.
Multiple sclerosis can have atypical presentations.Bulbar symptoms such as dysarthria and dysphagia can be initial symptoms of multiple sclerosis, although uncommon.Clinicians should be able to recognize multiple sclerosis with atypical onsets in order to make an early accurate diagnosis.
多发性硬化症(MS)是一种具有不同临床表现的复杂多因素疾病。球部症状,如构音障碍和吞咽困难,在晚期继发进展型疾病的MS患者中很常见。然而,在疾病发作时它们并不常见。我们报告一例17岁男性患者,最初表现为呕吐、构音障碍和吞咽困难。检查结果诊断为MS,脑干有活动性病变,更具体地说是在最后区区域。排除了鉴别诊断。患者接受静脉注射甲基泼尼松龙后症状有所改善。出院后开始使用芬戈莫德治疗。认识到具有非典型起病的MS对于早期准确诊断并为这种已知是年轻成年人神经残疾最常见原因之一的疾病开具适当治疗至关重要。
多发性硬化症可呈现非典型表现。构音障碍和吞咽困难等球部症状虽然不常见,但可为多发性硬化症的初始症状。临床医生应能够识别具有非典型起病的多发性硬化症以便进行早期准确诊断。