Sousa Bruno, Alves Rosa, Pestana Santos Catarina, Judas Tiago
Department of Internal Medicine, Hospital Garcia de Orta, Almada, Lisbon, Portugal.
Eur J Case Rep Intern Med. 2022 May 26;9(5):003312. doi: 10.12890/2022_003312. eCollection 2022.
Protein-losing enteropathy (PLGE) is an uncommon condition with a multifactorial origin, that is characterized by excessive loss of serum proteins into the gastrointestinal tract, resulting in hypoproteinaemia and oedema. The authors present the case of a 24-year-old man admitted to hospital for a 2-month history of lower extremity oedema and diarrhoea with a secretory pattern. Blood analysis revealed hypoalbuminaemia and iron deficiency anaemia. Liver disease and severe proteinuria were excluded as possible aetiologies. Upper gastrointestinal endoscopy revealed signs of chronic gastritis. After completion of eradication, the patient had complete resolution of clinical and laboratory abnormalities. The results suggest the need to consider less frequent aetiologies for peripheral oedema and hypoproteinaemia, such as PLGE, especially those caused by prevalent bacterial agents like .
Protein-losing enteropathy may be related to infection.Protein-losing enteropathy and its associated symptoms may be resolved by eradication.
蛋白丢失性肠病（PLGE）是一种病因多因素的罕见病症，其特征是血清蛋白过度丢失至胃肠道，导致低蛋白血症和水肿。作者介绍了一名24岁男性患者的病例，该患者因下肢水肿和分泌型腹泻2个月病史入院。血液分析显示低白蛋白血症和缺铁性贫血。排除了肝病和严重蛋白尿作为可能病因。上消化道内镜检查显示慢性胃炎迹象。根除治疗完成后，患者临床和实验室异常完全缓解。结果表明，对于外周水肿和低蛋白血症，需要考虑较少见的病因，如PLGE，尤其是由常见细菌病原体引起的病因。
蛋白丢失性肠病可能与感染有关。根除治疗可解决蛋白丢失性肠病及其相关症状。
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