Yamada M, Sumazaki R, Adachi H, Ahmed T, Matsubara T, Hori T, Nakahara A, Takita H
Department of Paediatrics, University of Tsukuba, Ibaraki, Japan.
Eur J Pediatr. 1997 Mar;156(3):182-5. doi: 10.1007/s004310050578.
There is as yet no consensus about the need for treatment of Helicobacter pylori infections, except for H. pylori-associated peptic ulcer. We present a 3-year-old boy with a 3-month history of oedema and hypoproteinaemia associated with hypertrophic gastropathy. Abdominal scintigram using intravenous 99mTc-labelled human serum albumin scintigraphy and direct measurement of protein in gastric juice proved that serum proteins were massively secreted in the stomach. Histological findings of mucosal inflammation were observed and H. pylori was isolated from the gastric mucosa. The protein loss promptly stopped within 2 weeks of the beginning of eradication therapy.
Protein-losing hypertrophic gastropathy may be induced by Helicobacter pylori-associated gastritis and should therefore be carefully evaluated by histological and bacteriological examination to provide a basis for eradication of H. pylori.
除幽门螺杆菌相关消化性溃疡外，对于幽门螺杆菌感染是否需要治疗尚无共识。我们报告一名3岁男孩，有3个月水肿和低蛋白血症病史，伴有肥厚性胃病。使用静脉注射99mTc标记的人血清白蛋白闪烁扫描法进行腹部闪烁扫描以及直接测量胃液中的蛋白质，证实血清蛋白大量分泌至胃内。观察到黏膜炎症的组织学表现，并且从胃黏膜中分离出幽门螺杆菌。在根除治疗开始后的2周内，蛋白质丢失迅速停止。
幽门螺杆菌相关性胃炎可能诱发蛋白丢失性肥厚性胃病，因此应通过组织学和细菌学检查进行仔细评估，为根除幽门螺杆菌提供依据。
