Zhang Guan-Meng, Nie Shao-Chen, Xu Zhao-Yuan, Fan Ya-Ru, Jiao Mai-Ning, Miao He-Jing, Liang Su-Xia, Yan Ying-Bin
Department of Oromaxillofacial-Head and Neck Surgery, Tianjin Stomatological Hospital, Hospital of Stomatology, Nankai University, Tianjin, China.
Tianjin Medical University, Tianjin, China.
Front Chem. 2022 Jun 14;10:927595. doi: 10.3389/fchem.2022.927595. eCollection 2022.
Oral cancer is one of the most common tumours in the world threatening human life and health. The 5-years survival rate of patients with oral cancer has not been improved significantly for many years. The existing clinical diagnostic methods rarely achieve early diagnosis due to deficiencies such as lack of sensitivity. Most of the patients have progressed to the advanced stages when oral cancer is detected. Unfortunately, the traditional treatment methods are usually ineffective at this stage. Therefore, there is an urgent need for more effective and precise techniques for early diagnosis and effective treatment of oral cancer. In recent decades, nanomedicine has been a novel diagnostic and therapeutic platform for various diseases, especially cancer. The synthesis and application of various nanoagents have emerged at the right moment. Among them, polymer nanoagents have unique advantages, such as good stability, high biosafety and high drug loading, showing great potential in the early accurate diagnosis and treatment of tumours. In this review, we focus on the application of advanced polymeric nanoagents in both the diagnosis and treatment of oral cancer. Then, the future therapy strategies and trends for polymeric nanoagents applied to oral cancer are discussed, with the hope that more advanced nanomedical technology will be applied to oral cancer research and promote the development of stomatology.
口腔癌是世界上最常见的威胁人类生命健康的肿瘤之一。多年来，口腔癌患者的5年生存率一直没有显著提高。由于缺乏敏感性等缺陷，现有的临床诊断方法很少能实现早期诊断。大多数患者在口腔癌被检测到时已进展到晚期。不幸的是，传统治疗方法在这个阶段通常无效。因此，迫切需要更有效、精确的技术用于口腔癌的早期诊断和有效治疗。近几十年来，纳米医学已成为各种疾病，尤其是癌症的新型诊断和治疗平台。各种纳米制剂的合成与应用应运而生。其中，聚合物纳米制剂具有独特的优势，如良好的稳定性、高生物安全性和高载药量，在肿瘤的早期精确诊断和治疗中显示出巨大潜力。在这篇综述中，我们重点关注先进聚合物纳米制剂在口腔癌诊断和治疗中的应用。然后，讨论了聚合物纳米制剂应用于口腔癌的未来治疗策略和趋势，希望更先进的纳米医学技术能应用于口腔癌研究并推动口腔医学的发展。
