Fan Ruiqi, Sun Yujun, Wang Mengxue, Wang Qian, Jiang Aifang, Yang Tingting
Center of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, China.
Front Mol Biosci. 2022 Jun 14;9:921298. doi: 10.3389/fmolb.2022.921298. eCollection 2022.
Ferroptosis is a new type of cell death different from apoptosis and necrosis, which can regulate the accumulation of lipid peroxidation through different pathways, ultimately leading to cell death. An increasing number of studies have revealed that the relationship between ferroptosis and cancer is extremely complex, which holds promise as a new treatment. In gynecological malignancies, ferroptosis has been found to have excellent antitumor activity, which can regulate the proliferation, metastasis and radiochemotherapy resistance. With the continuous progress of research, nanodrugs, gene therapy and other new therapeutic techniques for inducing ferroptosis have been proposed. However, the study of ferroptosis in gynecological malignancies is still in its infancy, and further research is needed to design safe and effective cancer therapies based on ferroptosis. This article reviews the mechanism of ferroptosis and the latest research progress and prospects in gynecological malignancies.
铁死亡是一种不同于凋亡和坏死的新型细胞死亡方式，它可通过不同途径调节脂质过氧化的积累，最终导致细胞死亡。越来越多的研究表明，铁死亡与癌症之间的关系极为复杂，有望成为一种新的治疗方法。在妇科恶性肿瘤中，已发现铁死亡具有出色的抗肿瘤活性，可调节肿瘤的增殖、转移及放化疗耐药性。随着研究的不断进展，已提出纳米药物、基因治疗等诱导铁死亡的新治疗技术。然而，妇科恶性肿瘤中铁死亡的研究仍处于起步阶段，需要进一步研究以设计基于铁死亡的安全有效的癌症治疗方法。本文综述了铁死亡的机制以及在妇科恶性肿瘤中的最新研究进展与前景。
